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BCAN Antibody

  • 中文名称：
    BCAN兔多克隆抗体
  • 货号：
    CSB-PA002590GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96GW7
  • 基因名：
    BCAN
  • 别名：
    BCAN antibody; BEHAB antibody; CSPG7 antibody; UNQ2525/PRO6018 antibody; Brevican core protein antibody; Brain-enriched hyaluronan-binding protein antibody; BEHAB antibody; Chondroitin sulfate proteoglycan 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BCAN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
  • 基因功能参考文献：
    1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    2. High Brevican is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
    3. s describe the expression of BEHAB/brevican in human brain and characterize two novel glioma-specific isoforms which are generated by differential glycosylation and are absent from normal adult brain and other neuropathologies. PMID: 16061654
    4. These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican. PMID: 16133547
    5. The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility PMID: 18611854

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  • 亚细胞定位：
    [Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 组织特异性：
    Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level).
  • 数据库链接：

    HGNC: 23059

    OMIM: 600347

    KEGG: hsa:63827

    STRING: 9606.ENSP00000331210

    UniGene: Hs.516904