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BAZ1A Antibody

  • 货号：
    CSB-PA140877
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA140877(BAZ1A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRL2
  • 基因名：
    BAZ1A
  • 别名：
    Acf1 antibody; ACF1; drosophila; homolog of antibody; ATP dependent chromatin remodelling protein antibody; ATP utilizing chromatin assembly and remodeling factor 1 antibody; ATP-dependent chromatin-remodeling protein antibody; ATP-utilizing chromatin assembly and remodeling factor 1 antibody; B930060C03 antibody; Baz1a antibody; BAZ1A_HUMAN antibody; BC065123 antibody; Bromodomain adjacent to zinc finger domain 1A antibody; Bromodomain adjacent to zinc finger domain protein 1A antibody; cbp146 antibody; CHRAC subunit ACF1 antibody; DKFZp586E0518 antibody; FLJ14383 antibody; Gtl5 antibody; hACF1 antibody; hWALp1 antibody; WALp1 antibody; WCRF180 antibody; Williams syndrome transcription factor related chromatin remodeling factor 180 antibody; Williams syndrome transcription factor-related chromatin-remodeling factor 180 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human BAZ1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.
  • 基因功能参考文献：
    1. Results from the study on gene variability in early stage embryos identifies BAZ1A as a putative variability marker of the 8-cell embryo stage. PMID: 26288249
    2. Results from the study suggest that acute cocaine exposure increased Baz1a expression in nucleus accumbens while repeated cocaine exposure produced the opposite effect. Findings implicate BAZ1A in molecular and behavioral plasticity to cocaine and offer new insight into the pathophysiology of cocaine addiction. PMID: 28412501
    3. promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin PMID: 29021563
    4. Study reports de novo mutation in BAZ1A, in a patient with a syndromic form of intellectual disability (ID). This mutation affects the expression of genes involved in several biological pathways such as vitamin D regulation, Wnt signaling, and postsynaptic signaling. Data point to an important role for BAZ1A in neurodevelopment, and highlight a possible link for BAZ1A to ID. PMID: 27328812
    5. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID: 25533843
    6. ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
    7. hACF1-containing factors are more generally involved in the DNA damage response. PMID: 21745822
    8. The ACF1 and its complexes play important roles in DNA double-strand breaks (DSBs) repair. PMID: 21172662
    9. The data support a model in which the human ACF anf yeast RSC remodeling enzymes move nucleosomes to new locations by a general sequence-independent mechanism. PMID: 19450608
    10. ACF1 alters the remodeling strategy of SNF2h PMID: 16877760
    11. Has a critical role in the transcriptional repression of specific nuclear hormone receptor-regulated genes. PMID: 17519354

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  • 亚细胞定位：
    Nucleus. Note=May target the CHRAC complex to heterochromatin.
  • 蛋白家族：
    WAL family
  • 组织特异性：
    Highly expressed in testis and at low or undetectable levels in other tissues analyzed.
  • 数据库链接：

    HGNC: 960

    OMIM: 605680

    KEGG: hsa:11177

    STRING: 9606.ENSP00000353458

    UniGene: Hs.509140