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BAIAP2L1 Antibody

  • 货号：
    CSB-PA794497
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HepG2 cells, using BAIAP2L1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BAIAP2L1 Polyclonal antibody
  • Uniprot No.：
    Q9UHR4
  • 基因名：
    BAIAP2L1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human BAIAP2L1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
  • 基因功能参考文献：
    1. Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology. PMID: 27278019
    2. IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38, and activation of small GTPases Rac1 and Cdc42. In addition, cells overexpressing IRTKS exhibited an increased polarity characterized by elongated cytoplasm and extensive lamellipodia at leading edges. PMID: 27693783
    3. Upregulation of BAIAP2L1 is associated with ovarian cancer. PMID: 26222696
    4. Lacking the Bin-Amphiphysin-Rvs (BAR) dimerization domain of BAIAP2L1. PMID: 25589496
    5. IRTKS can interact with epidermal growth factor receptor (EGFR), results in the phosphorylation of extracellular signal-regulated kinase PMID: 23693078
    6. Identification of a novel oncogenic FGFR3-BAIAP2L1 fusion protein in bladder cancer. PMID: 23175443
    7. These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells. PMID: 21887275
    8. data suggest Src-stimulated IRTKS phosphorylation is essential for its function in cell motility PMID: 21840312
    9. Results describe the NMR structure of insulin receptor tyrosine kinase substrate (IRTKS) SH3 domain in complex with a repeat from Escherichia coli-secreted protein F-like protein encoded on prophage U (EspF(U)). PMID: 21098279
    10. Study characterised IRTKS, which has widespread tissue distribution, is a substrate for the insulin receptor and binds Rac, and expression of IRTKS induces clusters of short actin bundles rather than filopodia-like protrusions. PMID: 17430976
    11. Screening of the mammalian SH3 proteome for the ability to bind EspF(U) identified the SH3 domain of insulin receptor tyrosine kinase substrate (IRTKS), a factor known to regulate the cytoskeleton. PMID: 19366662

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
  • 数据库链接：

    HGNC: 21649

    OMIM: 611877

    KEGG: hsa:55971

    STRING: 9606.ENSP00000005260

    UniGene: Hs.656063