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B4GALT3 Antibody

  • 货号：
    CSB-PA070130
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O60512
  • 基因名：
    B4GALT3
  • 别名：
    4-galactosyltransferase 3 antibody; 4-galactosyltransferase antibody; 4-GalTase 3 antibody; b4Gal T3 antibody; b4Gal-T3 antibody; B4GALT3 antibody; B4GT3_HUMAN antibody; Beta 1,4 galactosyltransferase 3 antibody; Beta 1,4 GalTase 3 antibody; Beta-1 antibody; Beta-N-acetylglucosaminyl-glycolipid beta-1 antibody; Beta4Gal T3 antibody; Beta4Gal-T3 antibody; Nal synthase antibody; UDP Gal:beta GlcNAc beta-1,4 galactosyltransferase 3 antibody; UDP-Gal:beta-GlcNAc beta-1 antibody; UDP-galactose:beta-N-acetylglucosamine beta-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human β-1,4-Gal-T3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
  • 基因功能参考文献：
    1. High-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that directly targets B4GALT3, leading to activation of beta1-integrin-NF-kappaappaB metastatic signaling in fibroblasts resulting in lung cancer. PMID: 29335551
    2. The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 are likely responsible for the pathogenesis of Primary Open-angle Glaucoma in this family. PMID: 27900994
    3. our findings evidenced that B4GALT3 upregulated by miR-27a contributes to the tumorigenic activities by b1-integrin pathway and might provide potential biomarkers for cervical cancer. PMID: 26987623
    4. Data suggest that expression of B4GALT3 in placenta is up-regulated in third trimester; over-expression of B4GALT3 in cultured trophoblasts suppresses cell migration; thus, B4GALT3 appears to regulate trophoblast invasion in late stages of pregnancy. PMID: 25659296
    5. beta-1,4-Galactosyltransferase III suppresses beta1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer. PMID: 24403309
    6. beta-1,4-Galactosyltransferase III enhances invasive phenotypes via beta1-integrin and predicts poor prognosis in neuroblastoma. PMID: 23444218

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
  • 蛋白家族：
    Glycosyltransferase 7 family
  • 组织特异性：
    Found in various tissues. Highest expression in placenta, prostate, testis, ovary, intestine and muscle, and in fetal brain.
  • 数据库链接：

    HGNC: 926

    OMIM: 604014

    KEGG: hsa:8703

    STRING: 9606.ENSP00000320965

    UniGene: Hs.321231