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B4GALNT2 Antibody

  • 货号：
    CSB-PA854161LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA854161LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) B4GALNT2 Polyclonal antibody
  • Uniprot No.：
    Q8NHY0
  • 基因名：
    B4GALNT2
  • 别名：
    4 N-acetylgalactosaminyltransferase 2 antibody; 4-GalNAc transferase antibody; 4-N-acetylgalactosaminyltransferase antibody; B4GALNT2 antibody; B4GALT antibody; B4GN2_HUMAN antibody; Beta 1,4 N-acetylgalactosaminyltransferase/betal,4 GalNAcT/Sda-GalNAcT antibody; Beta-1 antibody; beta-1,4-N-acetyl-galactosaminyl transferase 2 antibody; beta-4-N-acetylgalactosaminyltransferase antibody; CT-GalNAc transferase antibody; GALGT2 antibody; Sd(a) beta-1 antibody; sda beta-1,4-GalNAc transferase antibody; UDP-GalNAc:Neu5Aca2-3Galb-R b1 antibody; UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase antibody; UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Beta-1,4 N-acetylgalactosaminyltransferase 2 protein (301-566AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，B4GALNT2 Antibody (CSB-PA854161LA01HU)，的标记方式是Non-conjugated。对于B4GALNT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA854161LB01HU B4GALNT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA854161LC01HU B4GALNT2 Antibody, FITC conjugated
    Biotin CSB-PA854161LD01HU B4GALNT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.
  • 基因功能参考文献：
    1. B4GALNT2 overexpression prevented the infection of every avian influenza virus strain tested, including the H5, H9, and H7 subtypes, which have previously caused disease in humans. PMID: 28813663
    2. In normal colon samples a significant relationship between sLe(x) expression and the ratio between FUT6/B4GALNT2 activities exists, demonstrating for the first time a role for B4GALNT2 in sLe(x) inhibition in vivo. PMID: 24953560
    3. These experiments demonstrate successful transduction of rhesus macaque muscle with rAAVrh74.MCK.GALGT2 after vascular delivery and induction of molecular changes thought to be therapeutic in several forms of muscular dystrophy. PMID: 24145553
    4. molecular cloning; cDNA predicts a 566 aa protein showing 66.6% and 39% identity with mouse CT beta4GalNAc-T and human GM2/GD2 synthase PMID: 14688233
    5. A putative CpG island encompassing the promoter and exon 1 regions in the human Sd(a) beta4GalNAcT-II gene was identified. PMID: 17965433
    6. Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes PMID: 18485915

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 组织特异性：
    Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum.
  • 数据库链接：

    HGNC: 24136

    OMIM: 111730

    KEGG: hsa:124872

    STRING: 9606.ENSP00000300404

    UniGene: Hs.374679