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  4. Atp1a1 (Ab-23) Antibody

Atp1a1 (Ab-23) Antibody

  • 货号：
    CSB-PA779386
  • 规格：
    ￥2024
  • 图片：
    • Immunofluorescence analysis of HeLa cells, using ATP1α1/Na+K+ ATPase1 (Ab-23) antibody.
    • Western blot analysis of extracts from HeLa cells, using ATP1α1/Na+K+ ATPase1 (Ab-23) antibody.
    • Western blot analysis of extracts from K562 cells (Lane 2), using ATP1α1/Na+K+ ATPase1 (Ab-23) antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Atp1a1 Polyclonal antibody
  • Uniprot No.：
    P06685
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human ATP1α1/Na+K+ ATPase1 around the phosphorylation site of serine 23 (K-K-S(p)-K-K).
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • 基因功能参考文献：
    1. An antibody against the extracellular DR region (897-911) of Na(+)-K(+)-ATPase subunit alpha 1 disrupted the Na+-K+-ATPase/ROS amplifier and protected cultured cardiomyocytes from ROS-induced injury. PMID: 28181111
    2. overexpression of ATP1A1 is strongly associated with the presence and severity of N-nitrosomethylbenzylamine- and arecoline-induced esophageal squamous cell carcinoma in rats PMID: 27845894
    3. Direct carbonylation modification of Pro224 in the rat alpha1 subunit determines ouabain-mediated Na/K-ATPase signal transduction and subsequent regulation of renal proximal tubule sodium transport. PMID: 27613772
    4. Herein potential interaction between NTS1 receptor, dopaminergic D2 receptor and Na(+), K(+)-ATPase was studied.Results indicated that typical and atypical antipsychotic drugs differentially modulate the interaction between neurotensin and Na(+), K(+)-ATPase. PMID: 27586561
    5. These results suggest that decreased renal NHERF-1 expression contributes to the impaired dopamine-mediated inhibition of NKA in PTCs from animal models of hypertension. PMID: 28515088
    6. In contrast to Na/K-ATPase alpha1, alpha3 could not regulate Src. Upon exposure to ouabain, Src activation did not occur, yet ERK was activated through Src-independent pathways involving PI3K and PKC. Hence, alpha3 expression confers signaling and pumping properties that are clearly distinct from that of cells expressing Na/K-ATPase alpha1. PMID: 27903584
    7. Data show that Na(+)/K(+)-ATPase's DR-region specific monoclonal antibody and direct activator DRm217 increased Na(+)/K(+)-ATPase activity and alleviated Ca(2+) level. PMID: 27563007
    8. signaling through Na/K-ATPase regulates miRNAs and specifically, miR-29b-3p expression both in vivo and in vitro. PMID: 26702050
    9. Phosphorylation at Ser(938) is part of the mechanism by which ANG II directly stimulates activity and trafficking of the rat kidney Na-K pump in opossum kidney cells. PMID: 26582472
    10. protein kinase A and C activation can increase Na,K-ATPase activity in human muscle but not via P2Y receptor stimulation. PMID: 24614174
    11. Data suggest that, in polycystic ovary syndrome, heart exhibits down-regulation of both Na+/K+-ATPase (Na+/K+ transporting ATPase alpha 1) and eNOS (nitric oxide synthase 3) activities, but up-regulation of iNOS (nitric oxide synthase 2) activity. PMID: 25988879
    12. the PI 3-kinase/PKB signaling pathway is involved in the IGF-I-sustained basal (Na(+)/K(+))-ATPase activity during the first 7 days of the postnatal development of rat retina. PMID: 25274047
    13. Data indicate that ethylmalonic acid (EMA) injection reduced Na(+),K(+)-ATPase activity and glutathione concentrations, whereas malondialdehyde levels were increased. PMID: 25583115
    14. Data indicate that long-term regulation involves transcription and translation of the Na/K pump alpha1/2-isoforms, and short-term regulation involves the translocation of the alpha1/2-isoforms to the plasma membrane. PMID: 24903141
    15. Chronic and direct silencing of basolateral Na-K-ATPase uniquely regulates brush border membrane Na absorptive pathways in intestinal epithelial cells. Specifically, SGLT1 is stimulated secondary to enhanced affinity of the cotransporter. PMID: 25652450
    16. Data show that chronic malnutrition increases affinity for Na+ in renal Na+-ATPase. PMID: 25283821
    17. Data indicate that the oral administration of colestipol reduced the cholesterol content and concomitantly inhibited the (Na(+)/K(+))ATPase. PMID: 23829947
    18. effect of ovariectomy on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na(+),K(+)-ATPase alpha1 subunit in normotensive Wistar rats under a normal sodium or high sodium intake versus intact females PMID: 23327671
    19. Data indicate that overexpression of ouabain-insensitive rat Na(+)/K(+)-ATPase alpha1 failed to inhibit internalization of human Na(+)/K(+)-ATPase alpha1 expressed in the same cells. PMID: 24275648
    20. Suggest that the protective effect produced by increased expression of NKA-alpha2 on the heart after pressure overload is due to more efficient Ca2+ clearance because this isoform of NKA preferentially enhances NCX1 activity compared with NKA-alpha1. PMID: 24218169
    21. Data indicate that exposure to cobalt (Co) decreased Na(+)K(+)-ATPase activity in the cerebrum and cerebellum of suckling pups. PMID: 23857379
    22. genetic knockdown of the Na(+),K(+)-ATPase alpha1 subunit blocks peptide and starvation-induced autosis in vitro PMID: 24277826
    23. Mild hyperhomocysteinemia significantly decreases the activity and the content of the alpha 1 and alpha 2 subunits of the Na(+),K(+)-ATPase in cerebral cortex and hippocampus of adult rats. PMID: 23467881
    24. Identification of an ATP1A1 mutant that has normal pumping function but is defective in signal transduction. PMID: 23532853
    25. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction PMID: 23288841
    26. there is a specific and essential role for Na,K-ATPase alpha3 in neurons co-expressing alpha1 and alpha3 PMID: 23195960
    27. The present study demonstrated that sepsis induced by cecal ligation and puncture inhibits Na(+), K(+)-ATPase activity in a mechanism dependent on oxidative stress. PMID: 22810802
    28. Maintenance of Na(+),K(+)-ATPase cell surface abundance is critical to myocyte survival after an ischemic attack and plays a role in ouabain-induced myocardial protection. PMID: 23086991
    29. regulatory S-glutathionylation of the catalytic subunit plays a key role in the redox-induced regulation of Na,K-ATPase activity PMID: 22798075
    30. estrogen and progesterone act in renal tissues modulating CNG-A1 and Na/K ATPase gene expression PMID: 22759964
    31. in the kidney cortex of rats with renovascular hypertension there is increased expression of Na,K-ATPase and a selective increase in its phosphorylation at Ser-11 that could increase the capacity to reabsorb sodium and water. PMID: 22237155
    32. Angiotensin II changes the conformation of two forms of the sodium potassium ATPase alpha 1 subunit via differential phosphorylation PMID: 22145807
    33. PP2A inhibits association between the Na+,K+-ATPase and arrestin, and diminishes the effect of arrestin on Na+,K+-ATPase trafficking. PMID: 22242112
    34. Data suggest that during hypoxia, calcium entry via CRAC channels leads to AMPK activation, Na,K-ATPase downregulation, and alveolar epithelial dysfunction. PMID: 21730292
    35. These data strongly suggest the oxidative damage as one possible mechanism involved in the reduction of Na(+),K(+)-ATPase activity caused by hypermethioninemia. PMID: 21354298
    36. The abundance of Na-K-ATPase proteins was significantly decreased in basolateral membranes of type II alveolar epithelial cells in sepsis. PMID: 21478253
    37. Altered Na(+),K(+)-ATPase renal function may precede the development of age-related pathologies and loss of renal function. PMID: 20883770
    38. The unchanged expression of Na(+),K(+)-ATPase alpha1-subunit in both genders indicates that 8 weeks represent the time when the mobilization of enzyme synthesis observed previously in acute diabetes is lost. PMID: 20817950
    39. trafficking of the newly synthesized Na,K-ATPase is regulated by association with beta-COP PMID: 20801885
    40. these results suggest that the NH(2)-terminus of KCC3a is a key region for association with alpha1NaK, and that KCC3a but not KCC3b can regulate the Na(+),K(+)-ATPase activity. PMID: 20691666
    41. Results suggest that the association of NHE-1 with Na-K-ATPase is critical for ouabain-mediated regulation of Na-K-ATPase and that these effects may play a role in cardioglycoside-stimulated hypertension. PMID: 20427472
    42. Myosin-Va has a role in restraining Na(+)/K(+)-ATPase-containing vesicles within intracellular pools. PMID: 19808891
    43. In conclusion, pump activity not only affects neural activity directly but our results also suggest that pump activity is affected through functional interaction with DOR that will modulate pain sensation. PMID: 19619588
    44. Atp1a1 activity in VSMC and REC cells of rats, dog, and human show that Atp1a1 does not mediate the involvement of ouabain in the development of hypertension in rats, suggesting that the pathogenesis of human and rat hypertension may differ. PMID: 11926353
    45. FXYD7 decreases the apparent K(+) affinity of rat alpha 1-beta 1 and alpha 2-beta 1, but not of alpha 3-beta1 isozymes. PMID: 12093728
    46. alpha(1)- and alpha(2)-isoforms expressed under the same conditions suggest an involvement of the central ISR in the response to PKC but not in K(+) deocclusion. PMID: 12372782
    47. Interactions between Na,K-ATPase alpha-subunit ATP-binding domains may play a role in cell function and in modulating interactions between the Na,K-ATPase and other proteins PMID: 12511576
    48. Ang II modulates Na(+)-K(+)ATPase activity in PC-Cl3 cells through the AT1 receptor via activation of atypical PKC-zeta while the Ang II-activated PKC appears to have other as yet unknown functions. PMID: 12527732
    49. Chronic heart failure-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by exercise training. PMID: 12562669
    50. expression of Na/K ATPase alpha1 subunit mRNA was transiently increased in astrocytes after reoxygenation, whereas hypoxia itself did not induce any gene expression change. PMID: 12573531

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, axon. Melanosome.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
  • 组织特异性：
    Expressed in the central nervous system, in most motor and sensory axons of the ventral and dorsal roots, as well as in the large motor neurons of the ventral horn (at protein level).
  • 数据库链接：

    KEGG: rno:24211

    STRING: 10116.ENSRNOP00000045650

    UniGene: Rn.217534