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Acss2 Antibody

  • 中文名称：
    Acss2兔多克隆抗体
  • 货号：
    CSB-PA882544LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat heart tissue, Mouse heart tissue
      All lanes: Acss2 antibody at 4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 79 kDa
      Observed band size: 79, 50 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Acss2 Polyclonal antibody
  • Uniprot No.：
    Q9QXG4
  • 基因名：
    Acss2
  • 别名：
    Acss2 antibody; Acas2 antibody; Acecs1Acetyl-coenzyme A synthetase antibody; cytoplasmic antibody; EC 6.2.1.1 antibody; Acetate--CoA ligase antibody; Acetyl-CoA synthetase antibody; ACS antibody; AceCS antibody; Acetyl-CoA synthetase 1 antibody; AceCS1 antibody; Acyl-CoA synthetase short-chain family member 2 antibody; Acyl-activating enzyme antibody; Propionate--CoA ligase antibody; EC 6.2.1.17 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Rat
  • 免疫原：
    Recombinant Mouse Acetyl-coenzyme A synthetase, cytoplasmic protein (1-701AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Acss2 Antibody (CSB-PA882544LA01MO)，的标记方式是Non-conjugated。对于Acss2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882544LB01MO Acss2 Antibody, HRP conjugated ELISA
    FITC CSB-PA882544LC01MO Acss2 Antibody, FITC conjugated
    Biotin CSB-PA882544LD01MO Acss2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity.
  • 基因功能参考文献：
    1. ACSS2 promotes the systemic storage or metabolism of fat according to the fed or fasted state through the selective regulation of genes involved in lipid metabolism. PMID: 30228117
    2. results reveal a connection between cellular metabolism, gene regulation, and neural plasticity and establish a link between acetyl-CoA generation 'on-site' at chromatin for histone acetylation and the transcription of key neuronal genes. PMID: 28562591
    3. Study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. PMID: 25584894
    4. Study reports evidence that the nucleocytosolic ACSS2 enzyme is of critical importance for mammalian cells to utilize acetate as a source of acetyl-CoA, and that mice lacking this enzyme exhibit a substantial reduction in tumor burden in two genetic models of liver cancer. PMID: 25525877
    5. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine. In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2. PMID: 25525878
    6. Acss2 generates a specific pool of acetyl CoA during hypoxia that modulates interactions of the acetylase/coactivator Cbp (also known as Crebbp) with the stress-responsive transcription factor, Hif-2. Because erythropoietin is a Hif-2 target gene, red blood cell production in mice is also regulated by Acss2. Recovery from anemia is accelerated by administering acetate, although this requires the presence of Acss2. PMID: 25108527
    7. Acetyl CoA synthetase-1 (AceCS1) is mainly expressed in oligodendrocytes in the rat brain. It is located both in cytosol and nucleus of mammalian cells. PMID: 20533355
    8. Expression of cytosolic acetyl-CoA synthetase gene in mice is developmentally regulated PMID: 12049778
    9. ACSS2 might play a buffering role in tumor acetyl-CoA/acetate metabolism PMID: 19445015

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 数据库链接：

    KEGG: mmu:60525

    STRING: 10090.ENSMUSP00000029135

    UniGene: Mm.255026