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Acetyl-Histone H2B (K126) Antibody

  • 中文名称：
    Acetyl-Histone H2B (K126)兔多克隆抗体
  • 货号：
    CSB-PA000114
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using Acetyl-Histone H2B (K126) Polyclonal Antibody
    • Western Blot analysis of A549 cells using Acetyl-Histone H2B (K126) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96A08
  • 基因名：
    HIST1H2BA
  • 别名：
    HIST1H2BA antibody; testis antibody; bA317E16.3 antibody; H2B antibody; H2B histone family member U antibody; H2B histone family member U testis specific antibody; H2B histone family; member U; (testis specific) antibody; H2B testis antibody; H2B1A_HUMAN antibody; H2BFU antibody; H2BT antibody; HIST1H2BA antibody; Histone 1; H2ba antibody; Histone cluster 1 H2ba antibody; Histone H2B antibody; Histone H2B testis antibody; Histone H2B type 1 A antibody; Histone H2B type 1-A antibody; Histone H2B type 1A antibody; STBP antibody; Testis specific histone H2B antibody; Testis-specific histone H2B antibody; TSH 2B antibody; TSH2B antibody; TSH2B.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Human Histone H2B around the acetylation site of K126.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear.
  • 基因功能参考文献：
    1. In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
    2. Data indicate that lactate dehydrogenase A (LDHA) is involved in the transcription of histone 2B gene. PMID: 28257841
    3. Data show that histone H2B of prostate cancer cell line DU-145 have hypoacetylation, hypomethylation, and dephosphorylation, suggesting there was an excessive histone deacetylase activity in the cells. PMID: 26759222
    4. Reconstituted TSH2B containing octamers are able to form nucleosome core particles which are structurally and dynamically indistinguishable from those reconstituted with octamers consisting of only native histones. PMID: 15709765
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H2B family
  • 组织特异性：
    Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.
  • 数据库链接：

    HGNC: 18730

    OMIM: 609904

    KEGG: hsa:255626

    STRING: 9606.ENSP00000274764

    UniGene: Hs.591786