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  4. ATRN Antibody

ATRN Antibody

  • 货号：
    CSB-PA185232
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA185232(ATRN Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA185232(ATRN Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O75882
  • 基因名：
    ATRN
  • 别名：
    ATRN antibody; ATRN_HUMAN antibody; attractin 2 antibody; Attractin antibody; DPPT L antibody; DPPT-L antibody; KIAA0548 antibody; Mahogany homolog antibody; mahogany protein antibody; Mahogany, mouse, homolog of antibody; MGCA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ATRN
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system.
  • 基因功能参考文献：
    1. ATRN encodes Attractin, which was previously shown to play a critical role in central myelination PMID: 28493104
    2. Data indicate that Attractin was involved in male reproduction in both human and BALB/c mice, but it exerted a different expression profile in different species. PMID: 25318887
    3. The levels of both dipeptidyl-peptidase 4 and attractin in circulating monocytes were significantly higher in obese subjects as compared with levels in lean controls or in subjects with type 2 diabetes. PMID: 20198559
    4. associated with spermatozoa PMID: 19535787
    5. This protein is isolated from human blood and characterized. PMID: 12675230
    6. It is the first time expression of attractin on monocytes and provide first data suggesting that drugs directed to DP IV-like enzyme activity could affect monocyte function via attractin inhibition. PMID: 16835316
    7. The product of the murine "Mahogany" gene controls energy metabolism and is the murine orthologof human membrane attractin. PMID: 10086355
    8. Through use of PCR from hamster-human somatic cell hybrids, localizes the EST AB011120 (KIAA0548) to human chromosome 20p13. AB011120 encodes the central to 3' UTR of the membrane form of human attractin. PMID: 9628581
    9. The product of the murine "Mahogany" locus, controlling agouti-mediated melanocyte pigmentation and control of energy metabolism, is the murine ortholog of human attractin. PMID: 10086356
    10. Provides the genomic basis for production of a soluble and membrane form of attractin by alternative splicing. In the process, by sequencing from positionally-determined BAC clones, confirms the localization of attractin to chromosome 20p13. PMID: 10811918

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
  • 组织特异性：
    Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in
  • 数据库链接：

    HGNC: 885

    OMIM: 603130

    KEGG: hsa:8455

    STRING: 9606.ENSP00000262919

    UniGene: Hs.276252