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ATP8A2 Antibody

  • 货号：
    CSB-PA865134LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA865134LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA865134LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATP8A2 Polyclonal antibody
  • Uniprot No.：
    Q9NTI2
  • 基因名：
    ATP8A2
  • 别名：
    AT8A2_HUMAN antibody; ATP antibody; Atp8a2 antibody; ATPase aminophospholipid transporter class I type 8A member 2 antibody; ATPase aminophospholipid transporter like class I type 8A member 2 antibody; ATPase class I type 8A member 2 antibody; ATPase phospholipid transporting 8A2 antibody; ATPIB antibody; CAMRQ4 antibody; EC=3.6.3.1 antibody; IB antibody; ML-1 antibody; ML1 antibody; P4 ATPase flippase complex alpha subunit ATP8A2 antibody; Probable phospholipid-transporting ATPase IB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ATP8A2 Antibody (CSB-PA865134LA01HU)，的标记方式是Non-conjugated。对于ATP8A2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865134LB01HU ATP8A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA865134LC01HU ATP8A2 Antibody, FITC conjugated
    Biotin CSB-PA865134LD01HU ATP8A2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
  • 基因功能参考文献：
    1. Study describes a new ATP8A2 gene mutations associated with a novel syndrome that includes encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy. The data expand both the genetic and phenotypic spectrum associated with ATP8A2 gene mutations. PMID: 27679995
    2. ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait. PMID: 22892528
    3. CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2 PMID: 21454556
    4. P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes PMID: 19778899
  • 相关疾病：
    Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
  • 组织特异性：
    Strongly expressed in the brain, cerebellum, retina and testis.
  • 数据库链接：

    HGNC: 13533

    OMIM: 605870

    KEGG: hsa:51761

    STRING: 9606.ENSP00000371070

    UniGene: Hs.444957