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ATP6V0A1 Antibody

  • 货号：
    CSB-PA846292LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat brain tissue, Mouse brain tissue
      All lanes: ATP6V0A1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 97, 96 kDa
      Observed band size: 97 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA846292LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA846292LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The ATP6V0A1 antibody is designed to recognize the ATP6V0A1 proteins from human, mouse, and rat samples. When a rabbit received an injection of the recombinant human ATP6V0A1 protein (80-260aa), an immune response occurred in the rabbit producing large amounts of antibodies against the ATP6V0A1 protein. The rabbit's blood was collected and isolated to get the anti-serum, which underwent protein G purification to obtain the high-purity ATP6V0A1 polyclonal antibody (purity 95%+). This ATP6V0A1 antibody has accessed its specificity in ELISA, WB, IHC, and IF applications.

    The ATP6V0A1 protein, a subunit of the vacuolar ATPase (V-ATPase) enzyme, is specifically involved in the translocation of protons across the membrane and is essential for the proper functioning of the V-ATPase. It is responsible for maintaining the pH balance of the acidic compartments within the cell and plays a critical role in many cellular processes, including protein degradation, membrane trafficking, and ion homeostasis. Mutations in ATP6V0A1 have been linked to several disorders, including renal tubular acidosis and osteopetrosis.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATP6V0A1 Polyclonal antibody
  • Uniprot No.：
    Q93050
  • 基因名：
  • 别名：
    a1 antibody; ATP6N1 antibody; ATP6N1A antibody; ATP6V0A1 antibody; ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD) antibody; ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD) antibody; ATPase H+ transporting lysosomal V0 subunit a1 antibody; ATPase H+ transporting V0 subunit a1 antibody; ATPase, H+ transporting, lysosomal, noncatalytic accessory protein 1A antibody; Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit antibody; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit antibody; DKFZp781J1951 antibody; H(+) transporting two sector ATPase 116 kDa accessory protein A1 antibody; Stv1 antibody; V ATPase 116 kDa antibody; V ATPase 116 kDa isoform a1 antibody; V type proton ATPase 116 kDa subunit a antibody; V type proton ATPase 116 kDa subunit a isoform 1 antibody; V-ATPase 116 kDa isoform a1 antibody; V-type proton ATPase 116 kDa subunit a isoform 1 antibody; Vacuolar adenosine triphosphatase subunit Ac116 antibody; Vacuolar proton pump subunit 1 antibody; Vacuolar proton pump, subunit 1 antibody; Vacuolar proton translocating ATPase 116 kDa subunit A antibody; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 antibody; Vacuolar type H(+) ATPase 115 kDa subunit antibody; Vph1 antibody; VPP1 antibody; VPP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 1 protein (80-260AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ATP6V0A1 Antibody (CSB-PA846292LA01HU)，的标记方式是Non-conjugated。对于ATP6V0A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846292LB01HU ATP6V0A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA846292LC01HU ATP6V0A1 Antibody, FITC conjugated
    Biotin CSB-PA846292LD01HU ATP6V0A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle.
  • 基因功能参考文献：
    1. The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. PMID: 24072707
    2. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. ATP6V0A1 plays an important role in mediating autophagosome-lysosome fusion. PMID: 22708544
    3. a series of events whereby ATP6V0A1 3'-UTR variant T+3246C functioned: ATP6V0A1 expression probably was affected through differential micro-RNA effects, altering vacuolar pH and consequently CHGA processing and exocytotic secretion. PMID: 21558123
    4. The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters. PMID: 18505059
  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    V-ATPase 116 kDa subunit family
  • 数据库链接：

    HGNC: 865

    OMIM: 192130

    KEGG: hsa:535

    STRING: 9606.ENSP00000264649

    UniGene: Hs.463074