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ATP5C1 Antibody

  • 货号：
    CSB-PA000952
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using ATP5C1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P36542
  • 基因名：
  • 别名：
    ATP synthase gamma chain; mitochondrial antibody; ATP synthase subunit gamma antibody; ATP synthase subunit gamma; mitochondrial antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma polypeptide 1 antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; gamma subunit antibody; ATP5C 1 antibody; ATP5C antibody; ATP5C1 antibody; ATP5CL1 antibody; ATPG_HUMAN antibody; F ATPase gamma subunit antibody; F-ATPase gamma subunit antibody; mitochondrial antibody; Mitochondrial ATP synthase; gamma subunit 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ATP5C1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
  • 基因功能参考文献：
    1. Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation. PMID: 29499186
    2. These results demonstrated that the 5'-AGUUCCA-3' immediately downstream from ESE is a muscle-specific exonic splicing silencer (MS-ESS) responsible for exclusion of exon 9 in vivo and in vitro PMID: 11744705
    3. A report on the mechanism of exon skipping regulated by Fox-1, using the hF1gamma gene as a model system. PMID: 17686786
  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    ATPase gamma chain family
  • 组织特异性：
    Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta
  • 数据库链接：

    HGNC: 833

    OMIM: 108729

    KEGG: hsa:509

    STRING: 9606.ENSP00000349142

    UniGene: Hs.271135