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ATOH7 Antibody

  • 货号：
    CSB-PA850773ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA850773ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATOH7 Polyclonal antibody
  • Uniprot No.：
    Q8N100
  • 基因名：
    ATOH7
  • 别名：
    ATOH7 antibody; ATOH7_HUMAN antibody; Atonal homolog 7 (Drosophila) antibody; Atonal Homolog 7 antibody; bHLHa13 antibody; Class A basic helix-loop-helix protein 13 antibody; hATH5 antibody; Helix-loop-helix protein hATH-5 antibody; Math5 antibody; Protein atonal homolog 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein atonal homolog 7 protein (47-152AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract. Required for retinal circadian rhythm photoentrainment.
  • 基因功能参考文献：
    1. In conclusion, we have identified a homozygous mutation in the ATOH7 gene in a patient with nonsyndromic congenital retinal nonattachment. PMID: 26933893
    2. We evaluated 21 consanguineous NCRNA pedigrees and identified the causal mutations in known retinal genes in 13 out of our 21 families. We found mutations in ATOH7 in three families. PMID: 28192794
    3. We discovered a novel SNP, rs56238729 (P = 1.22 x 10-13), in the ATOH7-PBLD region that is significantly associated with VCDR in Latino individuals. PMID: 28061514
    4. The genotype and allele frequencies of the polymorphism in ATOH7 did not show any statistically significant association with primary open angle glaucomacompared to controls. PMID: 27617586
    5. Familial linkage studies for primary angle-closure glaucoma have been performed and identified ATOH7 causative primary angle-closure glaucoma disease PMID: 26497787
    6. Single nucleotide polymorphism in ATOH7 gene is associated with primary open angle glaucoma. PMID: 25798827
    7. The significant association of three common variants in TMCO1, ATOH7, and CAV1 with primary open angle, primary angle closure, and pseudoexfoliation glaucoma was found in Pakistani cohorts. PMID: 25489222
    8. Mutations within the ATOH7 gene are not implicated in the pathogenesis of optic nerve hypoplasia in our patient cohort. PMID: 23802135
    9. This study finds that ATOH7 is associated with optic disc size but not independently with cup/disk ratio. PMID: 24457358
    10. a bHLH mutation in ATOH7 causes recessive persistent hyperplasia of the primary vitreous PMID: 22645276
    11. findings document Mendelian mutations within ATOH7 and imply a role for this molecule in the development of structures at the front as well as the back of the eye; study provides further insights into the function of ATOH7, especially its importance in retinal vascular development and hyaloid regression PMID: 22068589
    12. combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma. PMID: 22222511
    13. Report Math5 expression/function in retinal ganglion cells. PMID: 22019371
    14. ATOH7 is significantly associated with open-angle glaucoma. PMID: 21427129
    15. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
    16. This study demonistrated that Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. PMID: 21441919
    17. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size PMID: 20395239

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  • 相关疾病：
    Persistent hyperplastic primary vitreous, autosomal recessive (PHPVAR)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 13907

    OMIM: 221900

    KEGG: hsa:220202

    STRING: 9606.ENSP00000362777

    UniGene: Hs.175396