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ATMIN Antibody

  • 货号：
    CSB-PA002304ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA002304ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATMIN Polyclonal antibody
  • Uniprot No.：
    O43313
  • 基因名：
    ATMIN
  • 别名：
    ASCIZ antibody; ATM INteracting protein antibody; ATM interactor antibody; ATM substrate CHK2-interacting zinc finger protein antibody; ATM/ATR substrate CHEK2 interacting zinc finger protein antibody; ATM/ATR Substrate Chk2 Interacting Zn++ finger protein antibody; ATM/ATR substrate Chk2 interacting Zn2+ finger protein antibody; ATM/ATR-substrate CHK2-interacting zinc finger protein antibody; ATMIN antibody; ATMIN_HUMAN antibody; DKFZp779K1455 antibody; FLJ76795 antibody; KIAA0431 antibody; Zinc finger protein 822 antibody; ZNF 822 antibody; ZNF822 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATM interactor protein (160-360AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.
  • 基因功能参考文献：
    1. The study results improve our understanding of the ATMIN-KRas axis leading to HNSCC migration or invasion and metastasis and facilitates the identification of possible therapy targets of downstream genes for designing effective therapeutic strategies in personalized medicine PMID: 28012797
    2. ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN. PMID: 28648892
    3. WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability. PMID: 26549024
    4. Studies suggest that ATM INteractor (ATMIN) could be an important biomarker in disease prognosis and treatment that might lighten the burden of chronic kidney disease and also affect on its progression. PMID: 27913685
    5. Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner. PMID: 26875667
    6. ATMIN is required for cell cycle progression and chromosome segregation following replication stress.ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. PMID: 25262557
    7. The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter. PMID: 22167198
    8. these results imply a potential cellular interference between DYNLL1 and ATMIN functions. PMID: 21971545
    9. Absence of Asciz (Atmin) leads to increased oxidative and methylating DNA base damage sensitivity in primary fibroblasts PMID: 20975950
    10. Asciz (Atmin) deletion or knock-down does not affect ATM levels and activation in mouse, chicken, or human cells PMID: 20975950
    11. ASCIZ acts as a lesion-specific focus scaffold in a Rad51-dependent pathway that resolves cytotoxic repair intermediates, most likely single-stranded DNA gaps, resulting from MLH1-dependent processing of base lesions. PMID: 15933716
    12. ATMIN defines a novel NBS1-independent pathway of ATM signalling. PMID: 17525732
    13. These data suggest that ASCIZ may affect the choice between competing base repair pathways in a manner that reduces the amount of substrates available for Ig gene conversion. PMID: 18433721
    14. ASCIZ (ATMIN) is structurally related to the yeast ATM/ATR substrate Mdt1 (Pin4/Ybl051c); both proteins contain SQ/TQ cluster domains and interact with N-terminal FHA domains of CHK2/Rad53 kinases. PMID: 18728389
    15. ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein (ASCIZ) required for repair of abasic sites after methylating and oxidative DNA damage but not double-strand breaks. Forms DNA damage-induced foci with RAD51 and ssDNA. ASCIZ foci depend on MLH1. PMID: 15933716

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  • 亚细胞定位：
    Nucleus. Note=Nuclear, in discrete foci during G1 phase.
  • 组织特异性：
    Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.
  • 数据库链接：

    HGNC: 29034

    OMIM: 614693

    KEGG: hsa:23300

    STRING: 9606.ENSP00000299575

    UniGene: Hs.16349