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ATIC Antibody

  • 货号：
    CSB-PA002299GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P31939
  • 基因名：
    ATIC
  • 别名：
    AICAR formyltransferase/IMP cyclohydrolase antibody; 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase antibody; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase antibody; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase antibody; AICAR antibody; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme antibody; AICAR transformylase antibody; AICARFT antibody; AICARFT/IMPCHASE antibody; ATIC antibody; Bifunctional purine biosynthesis protein PURH antibody; epididymis secretory sperm binding protein Li 70p antibody; FLJ93545 antibody; HEL-S-70p antibody; IMP cyclohydrolase antibody; IMP synthase antibody; IMP synthetase antibody; IMPCHASE antibody; Inosinicase antibody; OK/SW-cl.86 antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase antibody; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase antibody; PUR9_HUMAN antibody; PURH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ATIC
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能参考文献：
    1. ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling PMID: 29246230
    2. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study. PMID: 29042184
    3. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy PMID: 28267080
    4. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients. PMID: 27379764
    5. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events. PMID: 26799664
    6. genotyping of ATIC rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis. PMID: 25240429
    7. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    8. PTPLAD1 and AMPK are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC later accumulates in the Golgi/endosome fraction. PMID: 25687571
    9. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease. PMID: 25425682
    10. Our data show that ATIC is in complex with insulin receptor (IR)and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin stimulation and ATIC knockdown readily increase level of AMPK-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin response of Glut2 translocation in HEK293 cells and decreased AKT-Ser473 phosphorylation. PMID: 25687571
    11. MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy. PMID: 25084201
    12. study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment PMID: 24967362
    13. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly. PMID: 22180458
    14. The kinetic mechanism of the human bifunctional enzyme ATIC PMID: 11948179
    15. crystal structure of ATIC PMID: 14966129
    16. Deficiency in AICAR transformylase is associated with severe neurological defects and congenital blindness PMID: 15114530
    17. Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate. PMID: 15457444
    18. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058

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  • 相关疾病：
    AICAR transformylase/IMP cyclohydrolase deficiency (AICAR)
  • 蛋白家族：
    PurH family
  • 组织特异性：
    Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • 数据库链接：

    HGNC: 794

    OMIM: 601731

    KEGG: hsa:471

    STRING: 9606.ENSP00000236959

    UniGene: Hs.90280