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ATG9B Antibody

  • 货号：
    CSB-PA721119ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA721119ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA721119ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATG9B Polyclonal antibody
  • Uniprot No.：
    Q674R7
  • 基因名：
  • 别名：
    APG9 like 2 antibody; APG9-like 2 antibody; Apg912 antibody; APG9L2 antibody; Apgdc2 antibody; ATG9 autophagy related 9 homolog B (S. cerevisiae) antibody; Atg9b antibody; ATG9B_HUMAN antibody; Autophagy 9 like 2 protein antibody; Autophagy related protein 9B antibody; Autophagy-related protein 9B antibody; Endothelial nitric oxide synthase antisense antibody; eONE antibody; Gm574 antibody; Nitric oxide synthase 3 antisense antibody; Nitric oxide synthase 3 overlapping antisense gene protein antibody; Nitric oxide synthase 3-overlapping antisense gene protein antibody; NOS3AS antibody; Protein sONE antibody; SONE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Autophagy-related protein 9B protein (715-924AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. In addition to autophagy, also plays a role in necrotic cell death.
  • 基因功能参考文献：
    1. there is a close relationship between CRP and ATG9B in clear cell renal cell carcinomacarcinogenesis. PMID: 28923830
    2. This study highlights the transcriptional inactivation mechanisms of ATG2B, ATG4D, ATG9A and ATG9B promoter methylation status and the possible origin of autophagy signal pathway repression in invasive ductal carcinomas. PMID: 27265029
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19423540
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20406964
    7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20416077
    8. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20438785
    9. The role of Atg9 trafficking in yeast and mammalian autophagy, is summarised. PMID: 20083107
    10. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 19948975
    11. APG9L2 is highly expressed in placenta (trophoblast cells) and pituitary gland of adult tissues. PMID: 15755735
    12. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 19423521
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 19197948

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  • 亚细胞定位：
    Preautophagosomal structure membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ATG9 family
  • 组织特异性：
    Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.
  • 数据库链接：

    HGNC: 21899

    OMIM: 612205

    KEGG: hsa:285973

    UniGene: Hs.707300