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ATG9A Antibody

  • 货号：
    CSB-PA773782ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA773782ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATG9A Polyclonal antibody
  • Uniprot No.：
    Q7Z3C6
  • 基因名：
  • 别名：
    APG9 autophagy 9-like 1 antibody; APG9 like 1 antibody; APG9-like 1 antibody; APG9L1 antibody; ATG9 antibody; ATG9 autophagy related 9 homolog A antibody; ATG9 autophagy related 9 homolog A (S. cerevisiae) antibody; ATG9A antibody; ATG9A_HUMAN antibody; Autophagy 9-like 1 protein antibody; Autophagy related 9A antibody; Autophagy related protein 9A antibody; Autophagy-related protein 9A antibody; mATG9 antibody; MGD3208 antibody; OTTHUMP00000206046 antibody; OTTHUMP00000206048 antibody; OTTHUMP00000206049 antibody; OTTHUMP00000206062 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Autophagy-related protein 9A protein (180-290AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
  • 基因功能参考文献：
    1. the nucleation of autophagosomes occurs in endoplasmic reticulum ubulovesicular regions, where the ULK1 complex coalesces with ER and the ATG9 compartment PMID: 27510922
    2. the identification of ATG9A as a specific AP-4 cargo PMID: 29180427
    3. In the inner ear HEI-OC1 cell line, miR-34a overexpression resulted in an accumulation of phagophores and impaired autophagosome-lysosome fusion, and led to cell death subsequently. Notably, autophagy-related protein 9A (ATG9A), an autophagy protein, was significantly decreased after miR-34a overexpression. Knockdown of ATG9A inhibited autophagy flux, which is similar to the effects of miR-34a overexpression PMID: 28981097
    4. Contrary to its normal trafficking between plasma membrane, intracellular organelles and autophagic membranes, ATG9A concentrates in transferrin receptor-positive juxtanuclear recycling endosomes in SMPD1-deficient cells. PMID: 27070082
    5. Findings show for this first time that ATG9A loss in trastuzumab resistant cells allowed Her2 to escape from lysosomal targeted degradation through K63 poly-ubiquitination via c-Cbl. PMID: 27050377
    6. phosphorylation of mATG9 at Tyr8 by Src and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 and the AP1/2 complex. PMID: 27934868
    7. In these Rab1B-depleted cells, ATG9A accumulated in intermediate membrane structures at autophagosome formation sites. These results indicate that Rab1B is involved in regulating the proper development of autophagosomes. PMID: 28522593
    8. the C-terminal glycine of human ATG9A is required for its transport from the endoplasmic reticulum to the Golgi apparatus PMID: 27663665
    9. these findings provide new insights into the intracellular pathways followed by ATG9A to reach different subcellular compartments, and into the intramolecular determinants that drive the sorting of this protein. PMID: 27316455
    10. Results suggest that quinocetone stimulates the MRLC-mediated mAtg9 trafficking, which is critical for autophagosome formation, via the ATF6 upregulated expression of DAPK1. PMID: 27085326
    11. Importantly, TBC1D14 and TRAPPIII regulate ATG9 trafficking independently of ULK1. PMID: 26711178
    12. Data found that the interaction between 14-3-3 zeta and Atg9A is mediated by phosphorylation at Ser761. PMID: 25266655
    13. TBC1D5 and the AP2 complex are important novel regulators of the rerouting of ATG9-containing vesicular carriers toward sites of autophagosome formation. PMID: 24603492
    14. miR-29b mRNA, MAPK10 protein expression, and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma. PMID: 24767251
    15. the presence of ATG9A in the cytoplasm of tumor cells may be an independent biomarker for disease recurrence and survival in patients with oral squamous cell carcinoma PMID: 24085552
    16. These findings suggest that Bif-1 acts as a critical regulator of Atg9 puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation. PMID: 21068542
    17. mAtg9 trafficking through multiple organelles, including recycling endosomes, is essential for the initiation and progression of autophagy PMID: 22456507
    18. ATG9A was found by co-immunoprecipitation to interact with FAM48A/p38IP/q8NEM7.2. PMID: 19893488
    19. First demonstration that mammalian Atg9A, originally called mAtg9, is required for starvation-induced autophagy, and localizes to Golgi and endosomes. PMID: 16940348
    20. In human adult tissues APG9L1 is ubiquitously expressed. PMID: 15755735

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  • 亚细胞定位：
    Preautophagosomal structure membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ATG9 family
  • 数据库链接：

    HGNC: 22408

    OMIM: 612204

    KEGG: hsa:79065

    STRING: 9606.ENSP00000355173

    UniGene: Hs.323363