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ATG4C Antibody

  • 货号：
    CSB-PA097577
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells and COS7 cells, using ATG4C antibody.
    • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using ATG4C antibody.
    • Immunofluorescence analysis of HuvEc cells, using ATG4C antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ATG4C Polyclonal antibody
  • Uniprot No.：
    Q96DT6
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human ATG4C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能参考文献：
    1. association between SNPs and Kashin-Beck disease PMID: 27742532
    2. We demonstrate that, in breast cancer cells, ATM and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype. PMID: 28423511
    3. miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1. PMID: 22248718
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C54 family
  • 数据库链接：

    HGNC: 16040

    OMIM: 611339

    KEGG: hsa:84938

    STRING: 9606.ENSP00000322159

    UniGene: Hs.7353