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ASF1B Antibody

  • 中文名称：
    ASF1B兔多克隆抗体
  • 货号：
    CSB-PA030225
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NVP2
  • 基因名：
    ASF1B
  • 别名：
    Anti silencing function 1B antibody; Anti silencing function 1B histone chaperone antibody; Anti-silencing function protein 1 homolog B antibody; ASF1 anti silencing function 1 homolog B (S. cerevisiae) antibody; ASF1 anti silencing function 1 homolog B antibody; ASF1B antibody; ASF1B_HUMAN antibody; CCG1 interacting factor A II antibody; CCG1-interacting factor A-II antibody; CIA-II antibody; hAsf1 antibody; hAsf1b antibody; hCIA-II antibody; Histone chaperone ASF1B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ASF1B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.
  • 基因功能参考文献：
    1. histone binding to ASF1B is required for the induction of beta-cell proliferation. PMID: 27753532
    2. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function. PMID: 24598821
    3. Co-depletion of the histone chaperones ASF1a and ASF1b in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells. PMID: 24413054
    4. Data indicate that miR-214 down-regulated the expression of PSMD10 (gankyrin) and ASF1B, and gankyrin inhibition induced an increase of P53 mRNA levels. PMID: 23100276
    5. study of the interaction of the histone H3-H4 complex with the RbAp48 and their exchange with a second histone chaperone, anti-silencing function protein 1 (ASF1); exchange of histones H3-H4 between these two histone chaperones has a central role in the assembly of new nucleosomes PMID: 23178455
    6. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. PMID: 21179005
    7. Data show that Asf1b localizes with HCF-1 in viral replication foci and depletion of Asf1b results in significantly reduced viral DNA accumulation. PMID: 20133788
    8. Identify marks on histones H3-H4 bound to Asf1 and changes induced upon replication stress. PMID: 20227376
    9. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases. PMID: 20016786
    10. model is proposed in which the synergism between hAsf1 and CAF-1 for nucleosome formation during DNA repair is achieved through a transient physical interaction allowing histone delivery from Asf1 to CAF-1 [asf1(anti-silencing function 1)] PMID: 11897662
    11. data suggest that CIA-II is a histone chaperone and is implicated in the regulation of mammalian spermatogenesis PMID: 12842904
    12. Studies provide evidence for TLK1B-mediated phosphorylation of Asf1 triggering DNA repair. PMID: 17054786
    13. the expression of human ASF1A and ASF1B are upregulated followed by cell proliferation signal, but that of ASF1B is uniquely regulated by transcription factors E2F during cell cycle progression PMID: 17328667
    14. data link Asf1 chaperone function, histone supply, and replicative unwinding of DNA in chromatin; proposed that Asf1, as a histone acceptor and donor, handles parental and new histones at the replication fork via an Asf1-(H3-H4)-MCM2-7 intermediate PMID: 18096807
    15. ASF1A and ASF1B play a role in the efficiency of nucleosome assembly in vivo in human cells. PMID: 18378699

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ASF1 family
  • 组织特异性：
    Highly expressed in testis and at lower levels in colon, small intestine and thymus.
  • 数据库链接：

    HGNC: 20996

    OMIM: 609190

    KEGG: hsa:55723

    STRING: 9606.ENSP00000263382

    UniGene: Hs.26516