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ASCC3 Antibody

  • 货号：
    CSB-PA002198GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N3C0
  • 基因名：
    ASCC3
  • 别名：
    Activating signal cointegrator 1 complex subunit 3 antibody; ASC-1 complex subunit p200 antibody; ASC-1 complex subunit p200-KD subunit antibody; ASC1p200 antibody; ascc3 antibody; ATP binding 1 antibody; B630009I04Rik antibody; dJ121G13.4 antibody; DJ467N11.1 antibody; HELC1_HUMAN antibody; HELIC1 antibody; Helicase antibody; helicase; ATP binding 1 antibody; p200 antibody; RNA helicase family antibody; RNAH antibody; RP1-121G13.4 antibody; Trip4 complex subunit p200 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ASCC3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
  • 基因功能参考文献：
    1. UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. PMID: 28215706
    2. ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B. PMID: 26536629
    3. Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses. PMID: 23781071
    4. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184
  • 亚细胞定位：
    Nucleus. Nucleus speckle. Cytoplasm, cytosol.
  • 蛋白家族：
    Helicase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 18697

    OMIM: 614217

    KEGG: hsa:10973

    STRING: 9606.ENSP00000358159

    UniGene: Hs.486031