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ASB9 Antibody

  • 货号：
    CSB-PA002195GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96DX5
  • 基因名：
    ASB9
  • 别名：
    ASB9 antibody; Ankyrin repeat and SOCS box protein 9 antibody; ASB-9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human ASB9
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
  • 基因功能参考文献：
    1. Model of ASB9 in complex with its substrate, creatine kinase, reveals a mechanism for dynamic ubiquitin transfer. PMID: 27396830
    2. Molecular docking yielded a structural model consistent with all of the data that suggested the N-terminal residues of ASB9(1-252) may lie in one CK active site. This model was corroborated by enzymatic activity assays and mutational analysis. PMID: 25654263
    3. ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
    4. His103 and Phe107 in hASB9-2 are essential for binding to CKB. PMID: 22418839
    5. The results of the present study suggest that ASB9 is a useful prognostic marker for colorectal cancer PMID: 20878058
    6. ASB9 interacts with the creatine kinase system and negatively regulates cell growth. PMID: 20302626
    7. The splice variant of hASB9, hASB9-2 protein, was cloned, overexpressed, and crystallized and the data showed that the cubic hASB9-2 crystal belongs to space group P4(3)32 with unit-cell parameters. PMID: 18680464
    8. The purified ASB9-2 protein, the splice variant of ASB9 with only one ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution. PMID: 19275750

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Ankyrin SOCS box (ASB) family
  • 组织特异性：
    Predominantly expressed in testis, kidney, and liver.
  • 数据库链接：

    HGNC: 17184

    OMIM: 300890

    KEGG: hsa:140462

    STRING: 9606.ENSP00000369855

    UniGene: Hs.19404