ASB2 Antibody
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货号:CSB-PA064362
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:Q96Q27
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基因名:ASB2
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别名:ASB2Ankyrin repeat and SOCS box protein 2 antibody; ASB-2 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Fusion protein of Human ASB2
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2. Required during embryonic heart development for complete heart looping. Required for cardiomyocyte differentiation.; Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. Also targets DES for proteasomal degradation. Ac...显示更多
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基因功能参考文献:
- Notch signaling can initiate Asb2 transcription and NF-kappa B activation in T cell acute lymphoblastic leukemia cells. PMID: 30116272
- Using ASB2 conditional knockout mice. PMID: 26537633
- Phosphorylation of serine 323 of ASB2 alpha by Erk kinases is critical for ASB2alpha-mediated degradation of FLNA. PMID: 24044920
- data therefore reveal ubiquitin acceptor sites in FLNa and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins. PMID: 24052262
- Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK proteins in hematopoietic cells PMID: 22916308
- These results suggest that ASB2beta but not ASB2alpha might be monoubiquitinated and that the ASB2beta UIM motif, but not its E3 Ub ligase activity, plays a pivotal role in this monoubiquitination. PMID: 22382022
- A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL degradation and HOX gene down-regulation. PMID: 22174154
- ASB2alpha is a novel regulator of integrin-dependent adhesion of hematopoietic cells PMID: 21737450
- By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation. PMID: 21119685
- ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation. PMID: 18799729
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亚细胞定位:Cytoplasm, cytoskeleton, stress fiber.; [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line.
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蛋白家族:Ankyrin SOCS box (ASB) family
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组织特异性:[Isoform 1]: Expressed in muscle cells.; [Isoform 2]: Expressed in hematopoietic cells.
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数据库链接:
HGNC: 16012
OMIM: 605759
KEGG: hsa:51676
STRING: 9606.ENSP00000451575
UniGene: Hs.510327