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ASAP3 Antibody

  • 货号：
    CSB-PA837444LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ASAP3 antibody at 1µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Lane 3: K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 100, 44, 98 kDa
      Observed band size: 100 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA837444LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA837444LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ASAP3 Polyclonal antibody
  • Uniprot No.：
    Q8TDY4
  • 基因名：
  • 别名：
    9430088F20Rik antibody; ACAP4 antibody; ANK repeat and PH domain-containing protein 3 antibody; Arf GAP with SH3 domain antibody; Arf GAP with SH3 domain; ANK repeat and PH domain containing protein 3 antibody; Arf-GAP with SH3 domain antibody; ARF6 GTPase activating protein antibody; ArfGAP with SH3 domain; ankyrin repeat and PH domain antibody; ArfGAP with SH3 domain; ankyrin repeat and PH domain 3 1 antibody; ASAP3 antibody; ASAP3_HUMAN antibody; BOS_2358 antibody; Centaurin; beta 6 antibody; CENTB6 antibody; DDEFL1 antibody; Development and differentiation enhancing factor like 1 antibody; Development and differentiation-enhancing factor-like 1 antibody; FLJ20199 antibody; Gm140 antibody; MGC102639 antibody; MGC155101 antibody; OTTMUSP00000010435 antibody; Protein up-regulated in liver cancer 1 antibody; RP23-118A9.4 antibody; Up regulated in liver cancer 1 (UPLC1) antibody; UPLC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 protein (451-700AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ASAP3 Antibody (CSB-PA837444LA01HU)，的标记方式是Non-conjugated。对于ASAP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA837444LB01HU ASAP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA837444LC01HU ASAP3 Antibody, FITC conjugated
    Biotin CSB-PA837444LD01HU ASAP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes cell proliferation.
  • 基因功能参考文献：
    1. Results show that ASAP3 was amplified in colorectal cancer (CRC) tissues, and its upregulation was associated with poor prognosis of patients with CRC. Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO. These results suggest that ASAP3 acts as an oncogene. PMID: 28502111
    2. The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility PMID: 24284654
    3. ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion. PMID: 24078447
    4. Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling. PMID: 23776207
    5. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration PMID: 22027826
    6. The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface. PMID: 20510928
    7. ACAP4 is involved in ARF6-mediated cell migration. PMID: 16737952
    8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion. PMID: 18400762

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.
  • 数据库链接：

    HGNC: 14987

    OMIM: 616594

    KEGG: hsa:55616

    STRING: 9606.ENSP00000338769

    UniGene: Hs.437379