Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ARPIN Antibody

ARPIN Antibody

  • 货号：
    CSB-PA773801LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ARPIN antibody at 0.5µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25, 44 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA773801LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773801LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARPIN Polyclonal antibody
  • Uniprot No.：
    Q7Z6K5
  • 基因名：
    ARPIN
  • 别名：
    2610034B18Rik antibody; Actin related protein 2/3 complex inhibitor antibody; Arp2/3 inhibition protein antibody; ARPIN antibody; C15orf38 antibody; Chromosome 15 open reading frame 38 antibody; CO038_HUMAN antibody; Hypothetical protein LOC348110 antibody; MGC61550 antibody; RIKEN cDNA 2610034B18 antibody; UPF0552 protein C15orf38 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Arpin protein (1-226AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARPIN Antibody (CSB-PA773801LA01HU)，的标记方式是Non-conjugated。对于ARPIN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA773801LB01HU ARPIN Antibody, HRP conjugated ELISA
    FITC CSB-PA773801LC01HU ARPIN Antibody, FITC conjugated
    Biotin CSB-PA773801LD01HU ARPIN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
  • 基因功能参考文献：
    1. ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling. PMID: 28531800
    2. Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients PMID: 28293092
    3. Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins. PMID: 26774128
    4. Arpin downregulation may contribute to the initiation and development of breast cancer metastasis. PMID: 26648569
    5. Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis. PMID: 25892881

    显示更多

    收起更多

  • 亚细胞定位：
    Cell projection, lamellipodium.
  • 蛋白家族：
    Arpin family
  • 数据库链接：

    HGNC: 28782

    OMIM: 615543

    KEGG: hsa:348110

    STRING: 9606.ENSP00000350075

    UniGene: Hs.6734