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ARNT2 Antibody

  • 货号：
    CSB-PA080089
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9HBZ2
  • 基因名：
    ARNT2
  • 别名：
    ARNT protein 2 antibody; ARNT2 antibody; ARNT2_HUMAN antibody; Aryl hydrocarbon receptor nuclear translocator 2 antibody; bHLHe1 antibody; Class E basic helix-loop-helix protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Arnt 2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).
  • 基因功能参考文献：
    1. The single nucleotide polymorphisms rs4778599 in the gene encoding aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), showed an association that survived correction for multiple testing with emotion recognition of audio-visual stimuli in women PMID: 29194499
    2. Attenuated ARNT2 expression in HCC827 cells greatly promoted tumor growth. PMID: 25613063
    3. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
    4. Data suggest that selected human SIM1 (single-minded homolog 1) variants exhibit poor dimerization with ARNT2 and anomalous intracellular localization; these data were used to predict 'hot-spot' in SIM1/SIM2 (residues 290-326) critical for function. PMID: 24814368
    5. These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation. PMID: 24465693
    6. mutation of ARNT2 results in absence of detectable levels of ARNT2 transcript and protein from patient fibroblasts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and loss of ARNT2 function. PMID: 24022475
    7. In white males, rs4072568 in ARNT2 was also associated with BMI (P = 9 x 10(-4)) and % body fat (P = 0.001). PMID: 21512513
    8. ARNT2 might play an important role in the modulation of HIF-1-regulated signaling and metabolism. PMID: 21945317
    9. promotes differentiation of IL-22-producing CD4(+) T-cells PMID: 20706985
    10. There is no association of ARNT2 gene with cleft palate only (n = 45) and cleft lip/palate (n = 37). PMID: 12210012
    11. We thus propose that NDN regulates neuronal function and hypoxic response by regulating the activities of the ARNT2:SIM1 and ARNT2:HIF1alpha dimers, respectively. PMID: 17826745
    12. a possible use of ARNT2 and GST A1 as prognostic breast cancer biomarkers. PMID: 17899366

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  • 相关疾病：
    Webb-Dattani syndrome (WEDAS)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 16876

    OMIM: 606036

    KEGG: hsa:9915

    STRING: 9606.ENSP00000307479

    UniGene: Hs.459070