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ARMCX3 Antibody

  • 货号：
    CSB-PA030003
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UH62
  • 基因名：
    ARMCX3
  • 别名：
    ARMCX3 antibody; ALEX3 antibody; BM-017 antibody; UNQ2517/PRO6007Armadillo repeat-containing X-linked protein 3 antibody; ARM protein lost in epithelial cancers on chromosome X 3 antibody; Protein ALEX3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ARMCX3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.
  • 基因功能参考文献：
    1. reduction of Alex3 correlates with the development of non-small cell lung cancer and predicts adverse clinical outcome of non-small cell lung cancer patients. The effect of Alex3 on inhibiting invasion and migration may attribute to upregulation of E-cadherin expression through AKT-Slug pathway inactivation. PMID: 28705116
    2. The Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation. PMID: 23844091
  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus.
  • 蛋白家族：
    Eutherian X-chromosome-specific Armcx family
  • 数据库链接：

    HGNC: 24065

    OMIM: 300364

    KEGG: hsa:51566

    STRING: 9606.ENSP00000340672

    UniGene: Hs.592225