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ARL4C Antibody

  • 货号：
    CSB-PA002086LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA002086LA01HU at dilution of 1:100
    • Immunofluorescence staining of PC-3 cells with CSB-PA002086LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARL4C Polyclonal antibody
  • Uniprot No.：
    P56559
  • 基因名：
    ARL4C
  • 别名：
    ADP ribosylation factor like 4C antibody; ADP ribosylation factor like 7 antibody; ADP-ribosylation factor-like protein 4C antibody; ADP-ribosylation factor-like protein 7 antibody; ADP-ribosylation factor-like protein LAK antibody; Arl4c antibody; ARL4C_HUMAN antibody; ARL7 antibody; LAK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ADP-ribosylation factor-like protein 4C protein (2-192AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARL4C Antibody (CSB-PA002086LA01HU)，的标记方式是Non-conjugated。对于ARL4C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002086LB01HU ARL4C Antibody, HRP conjugated ELISA
    FITC CSB-PA002086LC01HU ARL4C Antibody, FITC conjugated
    Biotin CSB-PA002086LD01HU ARL4C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
  • 基因功能参考文献：
    1. We demonstrate that ARL4C knockdown likely attenuates osteogenesis of hASCs through inhibition of the Wnt signaling pathway. These results provide new insights into the mechanisms of osteogenic differentiation and provide a potential molecular target for bone tissue engineering. PMID: 29432742
    2. ARL4C is expressed due to hypomethylation in the 3'-UTR for certain types of cancers and that ARL4C methylation status is involved in squamous cell carcinoma cell function. PMID: 27835592
    3. Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis. PMID: 28053143
    4. Results indicated that overexpression of Arl4c might contribute to the tumorigenesis and might play a pivotal role in the progression of CRC. PMID: 26756615
    5. Arl4c is involved in tumorigenesis and might represent a novel therapeutic target for suppressing proliferation and invasion of colorectal and lung cancer cells. PMID: 25486429
    6. Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form. PMID: 17398095
    7. ARL7 might modulate the intracellular vesicular transport via interaction with microtubules. PMID: 19409876

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  • 亚细胞定位：
    Cell projection, filopodium. Cell membrane. Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 组织特异性：
    Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
  • 数据库链接：

    HGNC: 698

    OMIM: 604787

    KEGG: hsa:10123

    STRING: 9606.ENSP00000375057

    UniGene: Hs.111554