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ARL2BP Antibody

  • 货号：
    CSB-PA897097HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, U251 whole cell lysate, U87 whole cell lysate
      All lanes: ARL2BP antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 19, 18 kDa
      Observed band size: 19 kDa
    • IHC image of CSB-PA897097HA01HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARL2BP Polyclonal antibody
  • Uniprot No.：
    Q9Y2Y0
  • 基因名：
    ARL2BP
  • 别名：
    ADP ribosylation factor like 2 binding protein antibody; ADP-ribosylation factor-like protein 2-binding protein antibody; AR2BP_HUMAN antibody; Arf like 2 binding protein BART1 antibody; ARF-like 2-binding protein antibody; ARL2 binding protein antibody; Arl2bp antibody; ARL2BP protein antibody; BART antibody; BART1 antibody; Binder of ARF2 protein 1 antibody; Binder of Arl Two antibody; Binder of Arl2 antibody; Retinitis pigmentosa 66 (autosomal recessive) antibody; RP66 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (1-163AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARL2BP Antibody (CSB-PA897097HA01HU)，的标记方式是Non-conjugated。对于ARL2BP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897097HB01HU ARL2BP Antibody, HRP conjugated ELISA
    FITC CSB-PA897097HC01HU ARL2BP Antibody, FITC conjugated
    Biotin CSB-PA897097HD01HU ARL2BP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
  • 基因功能参考文献：
    1. This study identified two homozygous variants in ARL2BP as a rare cause of autosomal recessive retinitis pigmentosa. Further studies are required to define the underlying disease mechanism causing retinal degeneration as a result of mutations in ARL2BP and any phenotype-genotype correlation associated with residual levels of the wild-type transcript. PMID: 30210231
    2. Subsequent analysis of 844 index cases did not reveal further pathogenic chances in ARL2BP indicating that mutations in ARL2B are a rare cause of arRCD (about 0.1%) in a large cohort of French patients. PMID: 27790702
    3. Alteration of EBV encoded miR-BART1 expression results in an increase in migration and invasion of nasopharyngeal carcinoma in vitro and causes metastasis in vivo. EBV-miR-BART1 directly targets the cellular tumour suppressor PTEN. PMID: 26135619
    4. EBV also downregulates two immediate early genes by miR-BART20-5p. PMID: 24899173
    5. Mutations in ARL2BP cause autosomal-recessive retinitis pigmentosa. PMID: 23849777
    6. EBV-miR-BART1 could influence the expression of metabolism-associated genes and might be involved in cancer metabolism in nasopharyngeal carcinoma PMID: 23685147
    7. Our results imply that BART regulates actin-cytoskeleton rearrangements at membrane ruffles through modulation of the activity of Rac1, which, in turn, inhibits pancreatic cancer cell invasion. PMID: 22745590
    8. These results imply that BART contributes to regulating PKCalpha activity through binding to ANX7, thereby affecting the invasiveness of pancreatic cancer cells. PMID: 22532868
    9. We identify a subset of BART miRNAs that are restricted to Latency III in normal infection but are up regulated in tumors that express Latency I and II. PMID: 21901094
    10. Our results imply that BART increases active RhoA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells. PMID: 21833473
    11. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. PMID: 19368893

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  • 相关疾病：
    Retinitis pigmentosa with or without situs inversus (RPSI)
  • 亚细胞定位：
    Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    ARL2BP family
  • 组织特异性：
    Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
  • 数据库链接：

    HGNC: 17146

    OMIM: 615407

    KEGG: hsa:23568

    STRING: 9606.ENSP00000219204

    UniGene: Hs.632873