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ARIH2 Antibody

  • 货号：
    CSB-PA002069ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA002069ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARIH2 Polyclonal antibody
  • Uniprot No.：
    O95376
  • 基因名：
    ARIH2
  • 别名：
    HT005 antibody; all trans retinoic acid inducible RING finger antibody; Ari 2 antibody; Ari-2 antibody; ARI2 antibody; ARI2_HUMAN antibody; Ariadne 2 antibody; Ariadne 2 protein homolog antibody; ariadne homolog 2 (Drosophila) antibody; ariadne homolog 2 antibody; Ariadne RBR E3 ubiquitin protein ligase 2 antibody; ARIH 2 antibody; Arih2 antibody; E3 ubiquitin protein ligase ARIH2 antibody; E3 ubiquitin-protein ligase ARIH2 antibody; protein ariadne 2 homolog antibody; Protein ariadne-2 homolog antibody; Triad 1 antibody; TRIAD1 antibody; Triad1 protein antibody; UIP48 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase ARIH2 protein (194-493AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis.
  • 基因功能参考文献：
    1. these findings reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases PMID: 29021376
    2. We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation PMID: 24486325
    3. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. PMID: 24076655
    4. study demonstrated that TRIAD1 is a ubiquitination target for proteasome-dependent degradation by MDM2; results suggest TRIAD1 degradation by MDM2 suppresses TRIAD1-mediated cell growth; data suggested a novel negative regulatory mechanism of TRIAD1 via MDM2 E3 ligase ubiquitination PMID: 22940738
    5. TRIAD1 as a novel modulator of the p53-MDM2 axis that induces p53 activation by inhibiting its regulation by MDM2. PMID: 22819825
    6. In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover. PMID: 22037423
    7. HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1 PMID: 21454682
    8. proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells PMID: 16118314
    9. The fine-tuning of Gfi1 protein levels regulated by Triad1 defines an unexpected role for this protein in hematopoiesis. PMID: 17646546
    10. Triad1 has dual ubiquitin ligase activity; both its RING domains are crucial for inhibiting myeloid proliferation. The N-terminal RING finger (RING1) of Triad1 binds UbcH7; the C-terminal RING finger (RING2) binds Ubc13. PMID: 19340006

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    RBR family, Ariadne subfamily
  • 组织特异性：
    Widely expressed with higher expression in granulocytes.
  • 数据库链接：

    HGNC: 690

    OMIM: 605615

    KEGG: hsa:10425

    STRING: 9606.ENSP00000348769

    UniGene: Hs.633601