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ARHGEF17 Antibody

  • 货号：
    CSB-PA080066
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96PE2
  • 基因名：
    ARHGEF17
  • 别名：
    ARHGEF17 antibody; KIAA0337 antibody; TEM4Rho guanine nucleotide exchange factor 17 antibody; 164 kDa Rho-specific guanine-nucleotide exchange factor antibody; p164-RhoGEF antibody; p164RhoGEF antibody; Tumor endothelial marker 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p164-RhoGEF.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
  • 基因功能参考文献：
    1. data implicate TEM4 as an essential regulator of the actin cytoskeleton that ensures proper membrane protrusion at the leading edge of migrating cells and efficient cellular migration via suppression of actomyosin contractility PMID: 23825001
    2. Interaction of the central domain of ARHGEF17 with Mps1. PMID: 26953350
    3. The rho guanine nucleotide exchange factor 17 is drastically alter the effect of cGMP/cGK involving signaling pathways on RhoA-activated downstream effectors. PMID: 23195829
    4. TEM4 contains a novel actin binding domain and binding to actin is essential for TEM4 subcellular localization and activity. PMID: 22911862
    5. a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart PMID: 12071859
    6. Identification of ARHGEF17, mutations in melanoma. PMID: 18677770

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  • 组织特异性：
    Highly expressed in the heart.
  • 数据库链接：

    HGNC: 21726

    KEGG: hsa:9828

    STRING: 9606.ENSP00000263674

    UniGene: Hs.533719