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ARHGEF10 Antibody

  • 货号：
    CSB-PA000922
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using ARHGEF10 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O15013
  • 基因名：
    ARHGEF10
  • 别名：
    ARHGA_HUMAN antibody; ARHGEF10 antibody; DKFZp686H0726 antibody; GEF10 antibody; KIAA0294 antibody; MGC131664 antibody; Rho guanine nucleotide exchange factor (GEF) 10 antibody; Rho guanine nucleotide exchange factor 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ARHGEF10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in developmental myelination of peripheral nerves.
  • 基因功能参考文献：
    1. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
    2. This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population. PMID: 27934548
    3. A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found. PMID: 26143528
    4. Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). PMID: 21719701
    5. the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population PMID: 21743172
    6. The functional single-nucleotide polymorphism of ARHGEF10 confers the susceptibility to atherothrombotic stroke. PMID: 20042462
    7. data support a role for ARHGEF10 in developmental myelination of peripheral nerves PMID: 14508709
    8. Gef10 is the third member of a Rho-specific GEF family with unusual protein architecture PMID: 16896804
    9. A novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. PMID: 19635168

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  • 相关疾病：
    Slowed nerve conduction velocity (SNCV)
  • 数据库链接：

    HGNC: 14103

    OMIM: 608136

    KEGG: hsa:9639

    STRING: 9606.ENSP00000340297

    UniGene: Hs.98594