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ARHGAP1 Antibody

  • 货号：
    CSB-PA905307
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA905307(ARHGAP1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q07960
  • 基因名：
    ARHGAP1
  • 别名：
    ARHGAP 1 antibody; Arhgap1 antibody; CDC42 GTPase activating protein antibody; Cdc42 GTPase-activating protein antibody; CDC42GAP antibody; GTPase activating protein rhoOGAP antibody; GTPase-activating protein rhoOGAP antibody; GTPase-activating protein, Rho, 1 antibody; OTTHUMP00000233485 antibody; OTTHUMP00000233486 antibody; p50 RhoGAP antibody; p50-RhoGAP antibody; p50rhoGAP antibody; RHG01_HUMAN antibody; Rho GTPase activating protein 1 antibody; Rho GTPase-activating protein 1 antibody; Rho related small GTPase protein activator antibody; Rho type GTPase activating protein 1 antibody; Rho-related small GTPase protein activator antibody; Rho-type GTPase-activating protein 1 antibody; RHOGAP antibody; RHOGAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ARHGAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
  • 基因功能参考文献：
    1. identified ARHGAP1, which is a negative regulator of CDC42, as a novel, direct target of miR-130b PMID: 28748534
    2. to complete invasion of the endothelium, staphylococci reorient recycling endocytic vesicles to recruit Cdc42GAP. PMID: 27311480
    3. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs. PMID: 27616567
    4. study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells PMID: 24086303
    5. The interaction of RhoGap protein stabilizes the tetrameric conformation of p53 and enhances its DNA-binding activity, thereby inducing cell-cycle arrest and apoptosis. PMID: 23684608
    6. In PC3 cells, ARHGAP21 presented GAP activity for RhoA and RhoC and induced changes in cell morphology. Moreover, its silencing altered the expression of genes involved in cell proliferation and cytoskeleton organization PMID: 23200924
    7. RhoGAP Stard13 temporally and spatially regulates Rho activity in the developing pancreas to ensure that morphogenesis and establishment of tissue architecture are coordinated with organ growth. PMID: 23175628
    8. Rho proteins and ROK play a pivotal role in this signaling cascade PMID: 21051874
    9. PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth. PMID: 21169361
    10. Mutation of three residues of CDC42GAP involved in specific interactions of CDC42GAP with switch domain residues of Cdc42, as well as individual mutations of each of these residues, yields GAPs that are defective in stimulating GTP hydrolysis. PMID: 12501193
    11. phosphorylation of Y1214 on VEGFR2 is required to trigger the sequential activation of Cdc42 and SAPK2/p38 and to drive the SAPK2/p38-mediated actin remodeling in stress fibers in endothelial cells exposed to VEGF PMID: 14724572
    12. lipopolysaccharide-induced activation of the Rho family GTPase Cdc42, and we show its activation in the human neutrophil to be mediated by a p38 mitogen-activated protein kinase-dependent mechanism. PMID: 15262974
    13. CDC42GAP was identified as a counter-regulatory mediator for tubule formation. PMID: 18060510
    14. The NR5A1 gene expression was activated in mesenchymal stem cells by siRNA directed against RhoGAP (ARHGAP26). PMID: 18579725
    15. two potential interaction partners of Prx6: the calcium-activated cysteine endopeptidase calpain and the p50RhoGAP protein of the family of Sec14-like proteins. PMID: 18619034
    16. Results show that phorbol-ester-induced activation of protein kinases C and D stimulates association of DLC1 with 14-3-3 adaptor proteins, inhibiting RhoGAP activity and blocking nucleocytoplasmic transfer. PMID: 19066281

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 673

    OMIM: 602732

    KEGG: hsa:392

    STRING: 9606.ENSP00000310491

    UniGene: Hs.138860