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ARFIP1 Antibody

  • 货号：
    CSB-PA008866
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P53367
  • 基因名：
    ARFIP1
  • 别名：
    ADP ribosylation factor interacting protein 1 antibody; ADP-ribosylation factor-interacting protein 1 antibody; Arfaptin antibody; Arfaptin-1 antibody; ARFIP 1 antibody; Arfip1 antibody; ARFP1_HUMAN antibody; HSU52521 antibody; MGC117369 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Arfaptin 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
  • 基因功能参考文献：
    1. inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in fibrosarcoma cells PMID: 12606037
  • 亚细胞定位：
    Golgi apparatus. Golgi apparatus, trans-Golgi network membrane.
  • 组织特异性：
    Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.
  • 数据库链接：

    HGNC: 21496

    OMIM: 605928

    KEGG: hsa:27236

    STRING: 9606.ENSP00000296557

    UniGene: Hs.416089