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APBB1IP Antibody

  • 货号：
    CSB-PA001891GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z5R6
  • 基因名：
  • 别名：
    APBB1IP antibody; PREL1 antibody; RARP1 antibody; RIAMAmyloid beta A4 precursor protein-binding family B member 1-interacting protein antibody; APBB1-interacting protein 1 antibody; Proline-rich EVH1 ligand 1 antibody; PREL-1 antibody; Proline-rich protein 73 antibody; Rap1-GTP-interacting adapter molecule antibody; RIAM antibody; Retinoic acid-responsive proline-rich protein 1 antibody; RARP-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RIAM,APBB1IP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
  • 基因功能参考文献：
    1. s provide an overview of the structure and interactions of RIAM and discuss the implications of RIAM functions in innate and adaptive immunity and cancer. [Review] PMID: 28831022
    2. Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration. PMID: 26419705
    3. RIAM is a critical component of the phagocytosis machinery downstream of Rap1 and mediates its function by recruiting talin to the phagocytic complement receptors. PMID: 23420480
    4. integrin-triggered, RIAM-dependent MEK activation represents a key feedback event required for efficient focal adhesion disassembly. PMID: 22946047
    5. RIAM was recruited to the lymphocyte plasma membrane through its Ras association and pleckstrin homology domains, both of which were required for lymphocyte adhesion. PMID: 23045549
    6. RIAM might contribute to the dissemination of melanoma cells. PMID: 21454517
    7. by regulating the localization of PLC-gamma1, RIAM plays a central role in TCR signaling and the transcription of target genes. PMID: 19952372
    8. all-trans-retinoic acid-inducible RARP1 selectively affects signal transduction and may contribute to myeloid and megakaryocytic differentiation.(RARP1) PMID: 14530287
    9. Data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading. PMID: 15642358
    10. a minimized 50-residue Rap-RIAM module containing the talin binding site of RIAM joined to the membrane-targeting sequence of Rap1A. This minimized Rap-RIAM module was sufficient to target talin to the plasma membrane and to mediate integrin activation PMID: 19098287

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MRL family
  • 组织特异性：
    Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
  • 数据库链接：

    HGNC: 17379

    OMIM: 609036

    KEGG: hsa:54518

    STRING: 9606.ENSP00000365411

    UniGene: Hs.310421