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AP4M1 Antibody

  • 中文名称：
    AP4M1兔多克隆抗体
  • 货号：
    CSB-PA001883GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00189
  • 基因名：
    AP4M1
  • 别名：
    Adapter-related protein complex 4 mu-1 subunit antibody; Adaptor related protein complex 4 mu 1 subunit antibody; Adaptor related protein complex AP 4 mu4 subunit antibody; Adaptor related protein complex AP4 mu4 subunit antibody; Adaptor-related protein complex AP-4; mu 1 antibody; AP 4 adapter complex mu subunit antibody; AP 4 complex subunit mu 1 antibody; AP-4 adapter complex mu subunit antibody; AP-4 complex subunit mu-1 antibody; AP4 adapter complex mu subunit antibody; AP4 complex subunit mu 1 antibody; AP4M1 antibody; AP4M1_HUMAN antibody; Ap4m4 antibody; CPSQ3 antibody; MU 4 antibody; Mu adaptin related protein 2 antibody; MU ARP2 antibody; Mu subunit of AP 4 antibody; Mu subunit of AP-4 antibody; Mu-adaptin-related protein 2 antibody; mu-ARP2 antibody; mu4 antibody; Mu4-adaptin antibody; MUARP 2 antibody; MUARP2 antibody; SPG50 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human AP4M1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
  • 基因功能参考文献：
    1. analysis of the AP4M1 mutation associated with aggressive behavior in addition to mild dysmorphic features, intellectual disability, spastic paraparesis and reduced head circumference [case report] PMID: 25496299
    2. Results show that AP-4 can bind different types of cytosolic signals known to mediate basolateral transport in epithelial cells. Depletion of mu 4 results in the mis-sorting of several proteins in epithelial cells. PMID: 11802162
    3. AP-4 protein complex is involved in the regulation of somatodendritic-specific distribution of its cargo proteins including AMPA receptors. PMID: 18341993
    4. In all five patients with autosomal-recessive type of tetraplegic cerebral palsy with mental retardation, a donor splice site pathogenic mutation in intron 14 of the AP4M1 gene (c.1137+1G-->T), was identified. PMID: 19559397
  • 相关疾病：
    Spastic paraplegia 50, autosomal recessive (SPG50)
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome.
  • 蛋白家族：
    Adaptor complexes medium subunit family
  • 组织特异性：
    Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.
  • 数据库链接：

    HGNC: 574

    OMIM: 602296

    KEGG: hsa:9179

    STRING: 9606.ENSP00000352603

    UniGene: Hs.632317