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AP1M1 Antibody

  • 货号：
    CSB-PA863146ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: AP1M1 antibody at 1.43µg/ml
      Lane 1: A375 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: Hela whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 50 kDa
      Observed band size: 49 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA863146ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA863146ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AP1M1 Polyclonal antibody
  • Uniprot No.：
    Q9BXS5
  • 基因名：
    AP1M1
  • 别名：
    Adaptor protein complex AP-1 mu-1 subunit antibody; Adaptor-related protein complex 1 mu-1 subunit antibody; AP-1 complex subunit mu-1 antibody; AP-mu chain family member mu1A antibody; Ap1m1 antibody; AP1M1_HUMAN antibody; AP47 antibody; CLAPM2 antibody; Clathrin adaptor protein AP47 antibody; Clathrin assembly protein complex 1 medium chain 1 antibody; Clathrin assembly protein complex 1 medium chain antibody; Clathrin assembly protein complex AP1 mu subunit antibody; Clathrin coat assembly protein AP47 antibody; Clathrin coat-associated protein AP47 antibody; CLTNM antibody; Golgi adaptor AP 1 47 kDa protein antibody; Golgi adaptor HA1/AP1 adaptin mu-1 subunit antibody; HA1 47 kDa subunit antibody; MU 1A antibody; Mu-adaptin 1 antibody; Mu1A-adaptin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human AP-1 complex subunit mu-1 protein (1-160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • 基因功能参考文献：
    1. found 31 ORF9p interaction partners, among which was AP1M1, the mu subunit of the adaptor protein complex 1 (AP-1). AP-1 is a heterotetramer involved in intracellular vesicle-mediated transport and regulates the shuttling of cargo proteins between endosomes and the trans-Golgi network via clathrin-coated vesicles. PMID: 29793951
    2. Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. The basic patch on micro1 that interacts with the Nef acidic cluster also contributes to the binding of endogenous acidic cluster proteins. PMID: 28743825
    3. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B PMID: 25449265
    4. Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1. PMID: 23678182
    5. IRS-1 associates with mu1A of the ubiquitously expressed AP-1 complex through three protein interaction motifs. PMID: 23478262
    6. Mu1A binding to the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes. PMID: 22301137
    7. AP-1 mu1A is involved in the kAE1 trafficking of kidney alpha-intercalated cells PMID: 20833140
    8. These data identify the micro subunit of AP-1 (micro1) as the key target of the MHC-I CD/Nef complex, and they indicate that both Y320 in the MHC-I CD and E62-65 in Nef interact directly with micro1. PMID: 18057255

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  • 亚细胞定位：
    Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • 蛋白家族：
    Adaptor complexes medium subunit family
  • 数据库链接：

    HGNC: 13667

    OMIM: 603535

    KEGG: hsa:8907

    STRING: 9606.ENSP00000388996

    UniGene: Hs.71040