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ANO7 Antibody

  • 货号：
    CSB-PA776558
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from LOVO cells, using TM16G antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using TM16G antibody.
    • Immunofluorescence analysis of HepG2 cells, using TM16G antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ANO7 Polyclonal antibody
  • Uniprot No.：
    Q6IWH7
  • 基因名：
    ANO7
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human TM16G.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
  • 基因功能参考文献：
    1. high level of NGEP expression could be associated with good prognosis in prostate cancer PMID: 25808443
    2. NGEP protein is widely expressed in low-grade to high-grade prostate adenocarcinomas as well as benign prostate tissues, and the intensity of expression is inversely proportional to the level of malignancy. PMID: 23955683
    3. expressed only in prostate and prostate camcer is a promising target for the antibody-based therapies of prostate cancer PMID: 14981236
    4. Complete coding sequence of TMEM16G cDNA was determined by assembling 25 exons of TMEM16G gene PMID: 15375614
    5. description of the novel prostate-restricted molecule D-TMPP widely expressed in prostate cancer tissues PMID: 15761874
    6. NGEP is a glycoprotein with predicted glycosylation sites at N809 and N824. When these residues were converted to glutamine, glycosylation was abolished, confirming that the residues are extracellular PMID: 18676855
    7. NGEP is a potential target for T cell-mediated immunotherapy of prostate cancer. PMID: 19495750

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum.; [Isoform 2]: Cytoplasm, cytosol.
  • 蛋白家族：
    Anoctamin family
  • 组织特异性：
    Specifically expressed in epithelial cells of the prostate (at protein level).
  • 数据库链接：

    HGNC: 31677

    OMIM: 605096

    KEGG: hsa:50636

    STRING: 9606.ENSP00000274979

    UniGene: Hs.163909