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ANO6 Antibody

  • 货号：
    CSB-PA679761LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA679761LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ANO6 Polyclonal antibody
  • Uniprot No.：
    Q4KMQ2
  • 基因名：
  • 别名：
    2900059G15Rik antibody; AA407480 antibody; Ano6 antibody; ANO6_HUMAN antibody; Anoctamin 6 antibody; Anoctamin-6 antibody; AW554778 antibody; BDPLT7 antibody; F730003B03Rik antibody; MGC104751 antibody; SCTS antibody; TMEM16F antibody; Transmembrane protein 16F antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Anoctamin-6 protein (12-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ANO6 Antibody (CSB-PA679761LA01HU)，的标记方式是Non-conjugated。对于ANO6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA679761LB01HU ANO6 Antibody, HRP conjugated ELISA
    FITC CSB-PA679761LC01HU ANO6 Antibody, FITC conjugated
    Biotin CSB-PA679761LD01HU ANO6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
  • 基因功能参考文献：
    1. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. PMID: 28125837
    2. TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. PMID: 27287741
    3. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms PMID: 26108457
    4. deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID: 26481309
    5. ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. PMID: 26448322
    6. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. PMID: 26057829
    7. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID: 25651887
    8. using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
    9. Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis. PMID: 23618909
    10. a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population PMID: 23308121
    11. TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity. PMID: 23426967
    12. It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review) PMID: 22256604
    13. Study identified 2 novel mutations in the TMEM16F gene in 2 patients with Scott syndrome. PMID: 21511967
    14. Wild-type TMEM16F was localized on the plasma membrane and conferred Ca(2+)-dependent scrambling of phospholipids PMID: 21107324

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  • 相关疾病：
    Scott syndrome (SCTS)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
  • 蛋白家族：
    Anoctamin family
  • 组织特异性：
    Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
  • 数据库链接：

    HGNC: 25240

    OMIM: 262890

    KEGG: hsa:196527

    STRING: 9606.ENSP00000409126

    UniGene: Hs.505339