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ANKRD1 Antibody

  • 货号：
    CSB-PA001217
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using CARP Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15327
  • 基因名：
    ANKRD1
  • 别名：
    ALRP antibody; ANKR1_HUMAN antibody; ANKRD 1 antibody; ANKRD1 antibody; Ankyrin repeat domain 1 (cardiac muscle) antibody; Ankyrin repeat domain containing protein 1 antibody; Ankyrin repeat domain-containing protein 1 antibody; bA320F15.2 antibody; C 193 antibody; C193 antibody; Cardiac ankyrin repeat protein antibody; CARP antibody; CVARP antibody; Cytokine inducible nuclear protein antibody; Cytokine-inducible gene C-193 protein antibody; Cytokine-inducible nuclear protein antibody; HA1A2 antibody; Liver ankyrin repeat domain 1 antibody; MCARP antibody; OTTHUMP00000020084 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CARP.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
  • 基因功能参考文献：
    1. review of CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases [review] PMID: 27143260
    2. These data suggest that hepatitis C virus coopts ANKRD1 for its own propagation and up-regulation of ANKRD1 may contribute to hepatitis C virus-mediated liver pathogenesis. PMID: 26860204
    3. To the Ankrd1, it is not responsive to the cardiotoxic drug Doxorubicin, suggesting that different mechanisms govern their expression in cardiac cells. PMID: 25585647
    4. The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure. PMID: 25961010
    5. Report structure activity relationships for ANKRD1. PMID: 25125175
    6. ANKRD1 has a significant role in the regulation of apoptosis in human ovarian cancer cells PMID: 24531715
    7. Augmented CARP expression may be a common molecular event in failing hearts regardless of cardiomyopathic aetiology. PMID: 19359327
    8. Report impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. PMID: 23572067
    9. the 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min). PMID: 22892129
    10. Ankrd1 and desmin may play important roles in airway smooth muscle cell homeostasis. PMID: 22085644
    11. CARP and its regulator calpain 3 appear to occupy a central position in the important cell fate-governing NF-kappaB pathway in skeletal muscle PMID: 20860623
    12. p53 operates as an upstream effector of Ankrd1/CARP, by up regulating the proximal ANKRD1 promoter PMID: 20599664
    13. On the basis of genetic and functional analysis of CARP mutations, ANKRD1 has been identified as a new gene associated with dilated cardiomyopathy, accounting for approximately 2% of the 231 cases studied. PMID: 19525294
    14. CD45 lateral mobility is regulated by the spectrin-ankyrin cytoskeleton of T cells PMID: 20164196
    15. Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. PMID: 12054667
    16. CARP expression is observed by in situ hybridization in endothelial cells lining human atherosclerotic plaques, whereas lesion macrophages are devoid of CARP; it is induced by activin A in cultured intimal smooth muscle cells. PMID: 12524226
    17. endogenous ANKRD1 and calsequestrin are co-enriched in piglet cardiac Purkinje cells PMID: 15698842
    18. CARP interacts with itself and desmin. CARP, ankrd2, and DARP contain potential coiled-coil dimerization motifs within their unique aminoterminal domains that mediate the formation of homo-dimers. PMID: 16450059
    19. CARP was expressed in renal podocytes at a high level in 10 of 13 cases of crescentic glomerulonephritis, 7 of 19 cases of diabetic nephropathy, and 12 of 20 cases of lupus nephritis. PMID: 17239933
    20. cloned both translocation breakpoints and mapped the ANKRD1 gene, encoding a cardiac transcriptional regulator, 130 kb proximally to the breakpoint on chromosome 10, in total anomalous pulmonary venous return, a congenital heart defect PMID: 18273862
    21. Our results indicate that CARP is a sensitive and specific marker for rhabdomyosarcoma and that it will be useful for the differential diagnosis of rhabdomyosarcoma. PMID: 18656235
    22. We suggest that CDH1 cytoplasmic immunolocalization as a result of increased IGF-II levels identifies those nonmuscle invasive presentations most likely to recur PMID: 18980987
    23. Data show that ANKRD1 is a short-lived protein whose levels are tightly regulated by the 26S proteasome. PMID: 19589340
    24. ANKRD1 is a novel DCM gene, with mutations present in 1.9% of DCM patients. The ANKRD1 mutations may cause DCM PMID: 19608030
    25. CARP abnormalities may be involved in the pathogenesis of HCM. PMID: 19608031

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  • 相关疾病：
    Total anomalous pulmonary venous return (TAPVR)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
  • 数据库链接：

    HGNC: 15819

    OMIM: 106700

    KEGG: hsa:27063

    STRING: 9606.ENSP00000360762

    UniGene: Hs.448589