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AMOTL1 Antibody

  • 中文名称：
    AMOTL1兔多克隆抗体
  • 货号：
    CSB-PA007532
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8IY63
  • 基因名：
    AMOTL1
  • 别名：
    2310010G08Rik antibody; 2310067L22Rik antibody; 4932416D09Rik antibody; AMOL1_HUMAN antibody; Amotl1 antibody; Angiomotin-like protein 1 antibody; FLJ00155 antibody; JEAP antibody; Junction enriched and associated protein antibody; mFLJ00155 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Angiomotin-L1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
  • 基因功能参考文献：
    1. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. PMID: 26806348
    2. phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. PMID: 25373897
    3. miR-124 binds AmotL1 3'UTR and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells. PMID: 25218344
    4. These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs. PMID: 23793505
    5. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. PMID: 21685940
    6. By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein of parainfluenza virus 5 (PIV5). PMID: 19932912

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  • 亚细胞定位：
    Cell junction, tight junction.
  • 蛋白家族：
    Angiomotin family
  • 数据库链接：

    HGNC: 17811

    OMIM: 614657

    KEGG: hsa:154810

    STRING: 9606.ENSP00000387739

    UniGene: Hs.503594