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AMIGO2 Antibody

  • 货号：
    CSB-PA555803
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA555803(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA555803(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: SP20 cells, mouse heart tissue, Primary antibody: CSB-PA555803(AMIGO2 Antibody) at dilution 1/615, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q86SJ2
  • 基因名：
    AMIGO2
  • 别名：
    Adhesion molecule with Ig like domain 2 antibody; ALI 1 antibody; ALI1 antibody; Alivin 1 antibody; Alivin-1 antibody; Alivin1 antibody; AMGO2_HUMAN antibody; AMIGO 2 antibody; AMIGO-2 antibody; Amigo2 antibody; Amphoterin induced gene 2 antibody; Amphoterin induced protein 2 antibody; Amphoterin-induced gene and open reading frame 2 antibody; Amphoterin-induced protein 2 antibody; DEGA antibody; Differentially expressed in gastric adenocarcinoma antibody; Differentially expressed in gastric adenocarcinomas antibody; Transmembrane protein AMIGO 2 antibody; Transmembrane protein AMIGO2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AMIGO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
  • 基因功能参考文献：
    1. Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. PMID: 28272394
    2. this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. PMID: 29149598
    3. AMIGO2 is an important regulator of the PDK1-Akt pathway. PMID: 26553931
    4. Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. PMID: 12843293
    5. Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice. PMID: 15107827

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    Immunoglobulin superfamily, AMIGO family
  • 组织特异性：
    Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
  • 数据库链接：

    HGNC: 24073

    OMIM: 615690

    KEGG: hsa:347902

    STRING: 9606.ENSP00000266581

    UniGene: Hs.121520