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AMICA1 Antibody

  • 中文名称：
    AMICA1兔多克隆抗体
  • 货号：
    CSB-PA001668GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86YT9
  • 基因名：
    JAML
  • 别名：
    adhesion molecule AMICA antibody; Adhesion molecule interacting with CXADR antigen 1 antibody; adhesion molecule interacts with CXADR antigen 1 antibody; adhesion molecule that interacts with CXADR antigen 1 antibody; AMICA antibody; Amica1 antibody; CREA7-1 antibody; CREA7-4 antibody; Dendritic cell-specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-4 antibody; FLJ37080 antibody; Gm638 antibody; JAML1_HUMAN antibody; junctional adhesion molecule antibody; Junctional adhesion molecule-like antibody; Junctional adhesion molecule-like precursor antibody; MGC118814 antibody; MGC118815 antibody; UNQ722/PRO1387 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human AMICA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
  • 基因功能参考文献：
    1. expressed on leukocytes with a possible role in leukocyte transmigration PMID: 12869515
    2. Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state. PMID: 19064666
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
  • 数据库链接：

    HGNC: 19084

    OMIM: 609770

    KEGG: hsa:120425

    STRING: 9606.ENSP00000348635

    UniGene: Hs.16291