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AMD1 Antibody

  • 货号：
    CSB-PA776176
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA776176(AMD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA776176(AMD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, human seminoma tissue, mouse testis tissue, Primary antibody: CSB-PA776176(AMD1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P17707
  • 基因名：
    AMD1
  • 别名：
    Adenosylmethionine decarboxylase 1 antibody; AdoMetDC antibody; AMD1 antibody; DCAM_HUMAN antibody; EC 4.1.1.50 antibody; FLJ26964 antibody; S adenosylmethionine decarboxylase 1 antibody; S adenosylmethionine decarboxylase proenzyme antibody; S-adenosylmethionine decarboxylase beta chain antibody; SAMDC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human AMD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
  • 基因功能参考文献：
    1. AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation PMID: 29310120
    2. AMD1 is upregulated in human prostate cancer with activated mTORC1 PMID: 28658205
    3. AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark. PMID: 26558825
    4. Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders. PMID: 23260169
    5. This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex. PMID: 22008221
    6. Genetic variant of AMD1 is associated with obesity. PMID: 22496743
    7. Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants. PMID: 21134486
    8. Decreased AMD1 is associated with prostate cancer. PMID: 20215859
    9. AdoMetDC is ubiquitinated and degraded by the 26 S proteasome PMID: 14718534
    10. The adhesion-dependent expression of SAM-DC and ODC contributes to extracellular matrix-dependent salivary gland cell differentiation. PMID: 15521072
    11. For such cells, gamma-radiation and cisplatin, which are direct DNA-damaging agents, were very effective for promoting cell death. PMID: 17069747
    12. schizophrenia and bipolar disorder patients, the increase of S-adenosyl methionine is associated with an overexpression of DNA methyltransferase-1 mRNA in Brodmann's area 9 GABAergic neurons. PMID: 17259861
    13. Antisense RNA specifically inhibited the expression of ODC and AdoMetDC and the synthesis of polyamine, while it induced p21 expression, resulting in cell growth arrest in the G1 phase in prostate cancer cells PMID: 18548481
    14. Binding of putrescine to wild type dimeric ADOMETDC protein is cooperative; putrescine activates the enzyme through electrostatic effects and acts as a switch to correctly orient key catalytic residues. PMID: 19053272
    15. determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223 PMID: 19527050

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  • 蛋白家族：
    Eukaryotic AdoMetDC family
  • 数据库链接：

    HGNC: 457

    OMIM: 180980

    KEGG: hsa:262

    STRING: 9606.ENSP00000357880

    UniGene: Hs.159118