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ALX4 Antibody

  • 货号：
    CSB-PA884437LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat liver tissue
      All lanes: ALX4 antibody at 4.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ALX4 Polyclonal antibody
  • Uniprot No.：
    Q9H161
  • 基因名：
    ALX4
  • 别名：
    Alx4 antibody; ALX4_HUMAN antibody; Aristaless like homeobox 4 antibody; CRS5 antibody; FND2 antibody; FPP antibody; homeobox protein aristaless like 4 antibody; Homeobox protein aristaless-like 4 antibody; homeodomain transcription factor ALX4 antibody; KIAA1788 antibody; PFM1 antibody; PFM2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Homeobox protein aristaless-like 4 protein (112-216AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ALX4 Antibody (CSB-PA884437LA01HU)，的标记方式是Non-conjugated。对于ALX4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884437LB01HU ALX4 Antibody, HRP conjugated ELISA
    FITC CSB-PA884437LC01HU ALX4 Antibody, FITC conjugated
    Biotin CSB-PA884437LD01HU ALX4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • 基因功能参考文献：
    1. We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer PMID: 29183346
    2. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. PMID: 28081728
    3. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina PMID: 27349084
    4. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
    5. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
    6. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling. PMID: 24764194
    7. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer. PMID: 24037716
    8. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect PMID: 23401352
    9. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis. PMID: 22829454
    10. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    11. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    12. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
    13. data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland, and the loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of ductal carcinoma. PMID: 19783719
    14. ALX4 plays a critical role in craniofacial and epidermal development. PMID: 19692347
    15. One subject with parietal foramina whose deletion does not include ALX4 indicates that ALX4 in this subject may be rendered functionally haploinsufficient by a position effect. PMID: 15852040
    16. The ALX4 mutation p.R218Q tends to result in persistent cranium bifidum and is associated with anatomical abnormalities of the posterior fossa. PMID: 16319823

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  • 相关疾病：
    Parietal foramina 2 (PFM2); Frontonasal dysplasia 2 (FND2); Potocki-Shaffer syndrome (POSHS); Craniosynostosis 5 (CRS5)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expression is likely to be restricted to bone. Found in parietal bone.
  • 数据库链接：

    HGNC: 450

    OMIM: 601224

    KEGG: hsa:60529

    STRING: 9606.ENSP00000332744

    UniGene: Hs.436055