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ALPK2 Antibody

  • 货号：
    CSB-PA006868
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q86TB3
  • 基因名：
  • 别名：
    Alpha-protein kinase 2 antibody; ALPK2 antibody; ALPK2_HUMAN antibody; FLJ34875 antibody; FLJ43253 antibody; Gm549 antibody; HAK antibody; Heart alpha-protein kinase antibody; RGD1564431 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Alpha-protein Kinase 2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.
  • 基因功能参考文献：
    1. Results showed that p.Q1853E variant of ALPK2, which had been accumulating in the Japanese population, induced a metastatic phenotype of colorectal tumors by disrupting ALPK2 function. PMID: 28668886
    2. ALPK2 is crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. PMID: 22641666
  • 亚细胞定位：
    Basolateral cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily
  • 组织特异性：
    Expressed in developing cardiac tissue and cardiomyocytes (at protein level).
  • 数据库链接：

    HGNC: 20565

    KEGG: hsa:115701

    STRING: 9606.ENSP00000354991

    UniGene: Hs.628152