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ALKBH7 Antibody

  • 中文名称：
    ALKBH7兔多克隆抗体
  • 货号：
    CSB-PA001613GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BT30
  • 基因名：
    ALKBH7
  • 别名：
    ALKBH7 antibody; ABH7 antibody; SPATA11 antibody; UNQ6002/PRO34564 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7 antibody; mitochondrial antibody; EC 1.14.11.- antibody; Alkylated DNA repair protein alkB homolog 7 antibody; Spermatogenesis cell proliferation-related protein antibody; Spermatogenesis-associated protein 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ALKBH7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
  • 基因功能参考文献：
    1. Our results uncovered a SNP of ALKBH7, rs7540, which is associated with prostate cancer disease in a statistically significantly manner in two separate cohorts, and maintained in African American men. PMID: 28231280
    2. ALKBH7 possesses the conserved double-stranded beta-helix fold that coordinates a catalytically active iron by a conserved HX(D/E) em leader Xn em leader H motif. PMID: 25122757
    3. novel role for a AlkB homolog, human ALKBH7, in programmed necrosis, presenting a new target for therapeutic intervention in cancer cells that are resistant to apoptotic cell death PMID: 23666923
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    AlkB family
  • 组织特异性：
    Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
  • 数据库链接：

    HGNC: 21306

    OMIM: 613305

    KEGG: hsa:84266

    STRING: 9606.ENSP00000245812

    UniGene: Hs.111099