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ALDH3A1 Antibody

  • 货号：
    CSB-PA272721
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA272721(ALDH3A1 Antibody) at dilution 1/55, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA272721(ALDH3A1 Antibody) at dilution 1/55, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cells, mouse eye tissue, Primary antibody: CSB-PA272721(ALDH3A1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P30838
  • 基因名：
    ALDH3A1
  • 别名：
    Acetaldehyde dehydrogenase 3 antibody; AHD 4 antibody; AHD C antibody; AHD4 antibody; AHDC antibody; AL3A1_HUMAN antibody; Aldehyde dehydrogenase 3 antibody; Aldehyde dehydrogenase 3 family member A1 antibody; Aldehyde dehydrogenase 3A1 antibody; Aldehyde dehydrogenase antibody; Aldehyde dehydrogenase class 3 antibody; Aldehyde dehydrogenase dimeric NADP preferring antibody; Aldehyde dehydrogenase family 3 member A1 antibody; Aldehyde dehydrogenase family 3 subfamily A1 antibody; Aldehyde dehydrogenase family 3, subfamily A, member 1 antibody; Aldehyde dehydrogenase isozyme 3 antibody; Aldehyde dehydrogenase type III antibody; ALDH 3 antibody; ALDH 3A1 antibody; ALDH III antibody; ALDH, stomach type antibody; ALDH3 A1 antibody; ALDH3 antibody; ALDH3A 1 antibody; Aldh3a1 antibody; ALDHIII antibody; dimeric NADP-preferring antibody; MGC10406 antibody; Stomach aldehyde dehydrogenase antibody; Tumor associated aldehyde dehydrogenase tumor ALDH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ALDH3A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.
  • 基因功能参考文献：
    1. ALDH3A1 appears to play an essential role in protecting cellular proteins against aggregation under stress conditions PMID: 28526614
    2. ALDH3A1 confers a multi-modality resistance phenotype in MCF-7 cells PMID: 27276244
    3. Molecular docking analysis depicted that Sulforaphane fits into the active site of ALDH3A1, and facilitates the catalytic mechanism of the enzyme. PMID: 27997560
    4. ALDH-3A1 expression correlates well with gastric cancer dysplasia and grades, differentiation, lymph node metastasis and cancer stage. PMID: 27279633
    5. Down-regulation of ALDH3 activity in trophoblast stem cells initiates trophoblast differentiation during placental development. PMID: 26124079
    6. ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms PMID: 26751691
    7. Reported increased expression of ALDH3A1, PDIA3, and PRDX2 in pterygia using a proteomic approach. These proteins are presumed to have a protective role against oxidative stress-induced apoptosis. PMID: 25221425
    8. SiRNA-mediated suppression of ALDH3A1 blocked ALDH enzymatic activity and augmented cytotoxicity in CSE-exposed cells. PMID: 24316006
    9. While ALDH3A1 was not found in prostate glands, it was present in prostatic intraepithelial neoplasia, further increased in carcinomas, and upregulated in lymphatic metastases. ALDH3A1 increased in DU145-cell-derived lung metastasis vs. local xenografts. PMID: 24762960
    10. No correlation between ALDH3A1 expression and patient survival or tumour recurrence was observed.In conclusion, ALDH3A1 is a marker of activation of the Wnt/ss-catenin pathway in hepatocellular carcinoma PMID: 24276407
    11. ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress PMID: 22406320
    12. through modulation of PPARgamma or ALDH3A1, it may be possible to reduce cell proliferation in tumor cells or stimulate cell proliferation in normal cells during tissue regeneration. PMID: 21251908
    13. the UV-induced inactivation of ALDH3A1 is a result of non-native aggregation and associated structural changes rather than specific damage to the active site Cys PMID: 21203538
    14. Antihypertensives, nonopioid analgesics and hormonal contraceptives significantly affect the salivary ALDH3A1 activity. PMID: 21229876
    15. These findings suggest that a high level of expression of ALDH3 in cancerous liver tissues resulted from the expression or activation of at least two nuclear proteins reacting to the ALDH3 promoter region. PMID: 9855707
    16. ADH3*1 allele associated with high ADH activity and acetyaldehyde-DNA adducts in lung; may be a risk factor for lung cancer PMID: 12367788
    17. ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV-induced oxidative damage PMID: 12706498
    18. Enzyme activity and localization of ALDH3A1 in the cornea. PMID: 12943535
    19. ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle PMID: 15905174
    20. In most cases, ALDH3A1 activity in tumor and bordering tissues was higher than in a control group PMID: 18536178
    21. the mechanism of salivary ALDH3A1 inactivation must be related to free radical activity, presumably in the salivary gland, but it is not simply correlated with antioxidatn capacity of saliva PMID: 19894643

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 组织特异性：
    High levels in stomach, esophagus and lung; low level in the liver and kidney.
  • 数据库链接：

    HGNC: 405

    OMIM: 100660

    KEGG: hsa:218

    STRING: 9606.ENSP00000225740

    UniGene: Hs.531682