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ALDH1L1 Antibody

  • 货号：
    CSB-PA001569ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Cytosolic 10-formyltetrahydrofolate dehydrogenase antibody at 8μg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse gonad tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 99, 88, 100, 56 kDa
      Observed band size: 99 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA001569ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ALDH1L1 Polyclonal antibody
  • Uniprot No.：
    O75891
  • 基因名：
    ALDH1L1
  • 别名：
    10 formyltetrahydrofolate dehydrogenase antibody; 10 FTHFDH antibody; 10-formyltetrahydrofolate dehydrogenase antibody; 10-FTHFDH antibody; AL1L1_HUMAN antibody; Aldehyde dehydrogenase 1 family member L1 antibody; Aldehyde dehydrogenase family 1 member L1 antibody; aldh1l1 antibody; Cytosolic 10-formyltetrahydrofolate dehydrogenase antibody; DKFZp781N0997 antibody; EC 1.5.1.6 antibody; FDH antibody; formyltetrahydrofolate dehydrogenase antibody; FTHFD antibody; OTTHUMP00000155221 antibody; OTTHUMP00000214696 antibody; OTTHUMP00000214700 antibody; OTTHUMP00000222724 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytosolic 10-formyltetrahydrofolate dehydrogenase protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related hepatocellular carcinoma patients PMID: 28714006
    2. ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer PMID: 27384481
    3. high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients PMID: 27015121
    4. The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces. PMID: 28414156
    5. The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population. PMID: 26993122
    6. Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess of those required for classical one-carbon metabolism. [REVIEW] PMID: 26567272
    7. JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1. PMID: 25077544
    8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
    9. one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke. PMID: 24651765
    10. The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues PMID: 21987076
    11. Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme. PMID: 21540484
    12. These studies support ALDH1L1 as a general CNS astroglial marker. PMID: 21046559
    13. inhibition of cell motility by ALDH1L1 associated with dephosphorylation of the actin depolymerizing factor cofilin by PP1 and PP2A PMID: 20729910
    14. down-regulation of FDH in tumors is proposed to be one of the cellular mechanisms that enhance proliferation. PMID: 12065246
    15. FDH antiproliferative effects on A549 cells include both G(1) cell cycle arrest and caspase-dependent apoptosis PMID: 12805405
    16. None of the snps that defined 3 separate haplotype blocks in the FTHFD gene, rs2365004, rs11923466, rs2886059, rs10934751, rs2276731, rs1823213 and rs4646701 were associated with prostate cancer risk. PMID: 19064578

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GART family; Aldehyde dehydrogenase family, ALDH1L subfamily
  • 组织特异性：
    Highly expressed in liver, pancreas and kidney.
  • 数据库链接：

    HGNC: 3978

    OMIM: 600249

    KEGG: hsa:10840

    STRING: 9606.ENSP00000377083

    UniGene: Hs.434435