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AKIP1 Antibody

  • 货号：
    CSB-PA956447
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Jurkat cells, using BCA3 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using BCA3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AKIP1 Polyclonal antibody
  • Uniprot No.：
    Q9NQ31
  • 基因名：
    AKIP1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human BCA3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
  • 基因功能参考文献：
    1. These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8. PMID: 29520695
    2. Breast carcinoma-associated protein (BCA3) is packaged into Human immunodeficiency virus 1 (HIV-1) particles, and the BCA3 C-terminus is responsible for this incorporation. BCA3 incorporation into HIV-1 particles is mediated by its ability to interact with the catalytic subunit of protein kinase A. There is no effect of incorporated BCA3 on HIV-1 infectivity. PMID: 29677171
    3. The pleiotropic effects of BCA3 in HCC progression. PMID: 29133128
    4. The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression. PMID: 25526186
    5. Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis. PMID: 24413079
    6. Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity. PMID: 24659101
    7. Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart. PMID: 23319652
    8. action of PKA signaling on the NF-kappaB activation cascade PMID: 20562110
    9. characterization of the BCA3 gene; BCA3 is expressed in breast tumor cells in vivo, and not in surrounding stromal tissue PMID: 12527432
    10. AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits. PMID: 15630084
    11. AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus. PMID: 18178962

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  • 亚细胞定位：
    Nucleus. Note=Locates to punctate spots.
  • 组织特异性：
    Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain.
  • 数据库链接：

    HGNC: 1170

    OMIM: 609191

    KEGG: hsa:56672

    STRING: 9606.ENSP00000310459

    UniGene: Hs.131180