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AKAP7 Antibody

  • 货号：
    CSB-PA001529LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA001529LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001529LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA001529LA01HU at 1:120,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AKAP7 Polyclonal antibody
  • Uniprot No.：
    O43687
  • 基因名：
    AKAP7
  • 别名：
    A kinase (PRKA) anchor protein 7 antibody; A kinase anchor protein 18 kD antibody; A kinase anchor protein 7 antibody; A kinase anchor protein 7 isoform alpha antibody; A kinase anchor protein 7 isoform beta antibody; A kinase anchor protein 7 isoform gamma antibody; A kinase anchor protein 7 isoforms alpha and beta antibody; A kinase anchor protein 9 kDa antibody; A kinase anchoring protein 18 antibody; A-kinase anchor protein 18 kDa antibody; A-kinase anchor protein 7 isoforms alpha and beta antibody; AKA7A_HUMAN antibody; AKAP 18 antibody; AKAP 7 antibody; AKAP-7 isoforms alpha and beta antibody; AKAP15 antibody; AKAP18 antibody; Akap7 antibody; HGNC377 antibody; OTTHUMP00000040266 antibody; Protein kinase A anchoring protein 7 antibody; Protein kinase A anchoring protein 7 isoform alpha antibody; Protein kinase A anchoring protein 7 isoform beta antibody; Protein kinase A anchoring protein 7 isoform gamma antibody; Protein kinase A anchoring protein 7 isoforms alpha/beta antibody; Protein kinase A-anchoring protein 7 isoforms alpha/beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta protein (1-81AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AKAP7 Antibody (CSB-PA001529LA01HU)，的标记方式是Non-conjugated。对于AKAP7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001529LB01HU AKAP7 Antibody, HRP conjugated ELISA
    FITC CSB-PA001529LC01HU AKAP7 Antibody, FITC conjugated
    Biotin CSB-PA001529LD01HU AKAP7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
  • 基因功能参考文献：
    1. AKAP7 expression levels may have clinical utility as a prognostic biomarker for post-stroke blood brain complications PMID: 28446746
    2. Malonate in the nucleotide-binding site traps human AKAP18-gamma in a novel conformational state. PMID: 27487922
    3. PKC tethered to AKAP7alpha was less susceptible to inhibition from the ATP-competitive inhibitor Go6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C. PMID: 24302730
    4. Data from studies using recombinant proteins suggest that both AKAP7-gamma and AKAP7-alpha exhibit high-affinity interactions with isoenzymes of PKC (protein kinase C); AKAP7 could dictate PKC localization/function. PMID: 22670899
    5. AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes PMID: 12804576
    6. AKAP15 regulates ENaC via a novel PKA-independent pathway PMID: 17244820
    7. AKAP18 contains a phosphodiesterase domain that binds AMP. PMID: 18082768

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  • 亚细胞定位：
    [Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
  • 组织特异性：
    Expressed in brain, heart, lung, pancreas and skeletal muscle.
  • 数据库链接：

    HGNC: 377

    OMIM: 604693

    UniGene: Hs.486483